心力衰竭合并肺部感染患者血清RAAS与MMP及TIMP指标的变化研究

发布时间：2018-04-01 12:19

本文选题：心力衰竭　切入点：肺部感染　出处：《中华医院感染学杂志》2017年06期

【摘要】：目的观察及研究心力衰竭合并肺部感染患者血清RAAS、MMP及TIMP指标的变化情况,为心力衰竭合并肺部感染患者的防控及诊治提供依据。方法选取医院2014年6月-2016年3月收治的46例心力衰竭合并肺部感染患者为A组,并选取同时间段的46例单纯心力衰竭患者为B组,46名同龄体检健康者为C组,然后将三组研究对象的血清RAAS、MMP及TIMP指标进行比较,并比较A组中不同肺部感染程度者的血清RAAS、MMP及TIMP指标水平。结果 A组血清RAAS指标中的Ang-Ⅱ、ALD及NE水平分别为(65.75±5.24)ng/L、(39.45±3.36)ng/L及(71.50±6.48)ug/L,均高于B组(58.45±4.63)ng/L、(32.52±2.73)ng/L、(62.62±5.48)ug/L及C组(37.45±3.80)ng/L、(18.40±1.73)ng/L、(33.23±3.13)ug/L,血清MMP及TIMP指标水平分别差于B组及C组,B组则差于C组,且A组不同肺部感染程度者的血清RAAS、MMP及TIMP指标水平差异明显,P0.05,差异均有统计学意义。结论心力衰竭合并肺部感染患者血清RAAS、MMP及TIMP指标呈现高表达状态,应重视对此类患者上述血清指标的监控与改善。
[Abstract]:Objective to observe and study the changes of serum RAAS-MMP and TIMP in patients with heart failure and pulmonary infection. Methods 46 patients with heart failure and pulmonary infection were selected as group A from June 2014 to March 2016. 46 patients with simple heart failure in the same time period were selected as group B and 46 healthy persons of the same age as group C, then the serum RAAS-MMP and TIMP indexes of the three groups were compared. The serum levels of RAAS-MMP and TIMP in group A were compared with those in group A (65.75 卤5.24ng / L) and 71.50 卤6.48ng / L respectively, which were higher than those in group B (58.45 卤4.63ng / L) and group C (37.45 卤3.80ng / L 18.40 卤3.73ng / L), respectively, and the levels of serum MMP and TIMP were 33.23 卤3.13ugr / L, respectively, and were higher than those in group B (58.45 卤4.63 ng / L) and group C (37.45 卤3.80 ng / L), respectively. Compared with group B and group C, group B was worse than group C, respectively. In group A, the levels of serum RAAS-MMP and TIMP in patients with pulmonary infection were significantly different (P 0.05). Conclusion the levels of serum RAAS-MMP and TIMP in patients with heart failure and pulmonary infection are highly expressed. Attention should be paid to the monitoring and improvement of the above mentioned serum indexes in such patients.
【作者单位】：驻马店市中心医院心内三科;正阳县人民医院心内科;驻马店市中心医院内分泌科;
【基金】：河南省教育厅科学技术研究重点基金资助项目(142102310010)
【分类号】：R563.1;R541.6

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