血清微量元素含量对脑梗死患者肺部感染的预测评价及与红细胞免疫与炎症反应的相关性

发布时间：2018-04-17 02:10

本文选题：脑梗死 + 肺部感染　；参考：《中华医院感染学杂志》2017年15期

【摘要】：目的探讨血清微量元素含量对脑梗死患者肺部感染的预测价值及其与红细胞免疫、炎症反应的相关性。方法选取2013年5月-2015年12月于医院接受治疗的脑梗死患者114例,根据入院24h后发生肺部感染情况分为合并肺部感染组53例、单纯脑梗死组61例;采用酶联免疫吸附法(ELISA)检测血清微量元素及炎症因子含量,流式细胞仪检测外周血红细胞免疫参数。结果入院48h,合并肺部感染组的血清微量元素钙(Ca)、镁(Mg)、锌(Zn)含量低于单纯脑梗死组(P0.05);外周血免疫黏附抑制因子(FEIR)水平以及血清C-反应蛋白(CRP)、白细胞介素-6(IL-6)、白细胞介素-17(IL-17)、肿瘤坏死因子-α(TNF-α)含量高于单纯脑梗死组患者;Pearson检验发现,脑梗死合并肺部感染患者的血清Ca、Mg、Zn含量与红细胞免疫、炎症反应呈相关关系。结论血清微量元素含量对脑梗死患者肺部感染具有良好预警价值,与病情严重程度直接相关。
[Abstract]:Objective to investigate the predictive value of serum trace element content in pulmonary infection in patients with cerebral infarction and its correlation with erythrocyte immunity and inflammation.Methods 114 patients with cerebral infarction who were treated in hospital from May 2013 to December 2015 were divided into three groups according to the pulmonary infection after 24 hours: 53 patients with pulmonary infection and 61 patients with simple cerebral infarction.The contents of trace elements and inflammatory factors in serum were detected by Elisa and the immune parameters of peripheral red blood cells were measured by flow cytometry.Results at 48 hours after admission, the contents of serum trace elements such as calcium, magnesium, magnesium, zinc and zinc in patients with pulmonary infection were lower than those in patients with simple cerebral infarction (P0.05), the levels of peripheral blood immunoadhesive inhibitor (FEIRR), serum C-reactive protein (CRPU), interleukin-6 (IL-6), interleukin-6 (IL-6), leukocyte mesenchyma (WBC) in the patients with pulmonary infection were lower than those in the patients with cerebral infarction.The levels of tumor necrosis factor- 伪 (TNF- 伪) in patients with simple cerebral infarction were higher than those in patients with simple cerebral infarction by Pearson test.There was a correlation between the content of serum CaAMgO Zn and erythrocyte immunity and inflammatory reaction in patients with cerebral infarction complicated with pulmonary infection.Conclusion the content of trace elements in serum has good early warning value for pulmonary infection in patients with cerebral infarction and is directly related to the severity of the disease.
【作者单位】：天津市第四中心医院神经内科;天津市第四中心医院胸外科;
【分类号】：R563.1;R743.3

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