二陈汤加味对慢性阻塞性肺疾病急性加重期老年患者免疫功能及CCL18,CC16,IL-8和sICAM-1的影响

发布时间：2018-05-01 12:37

本文选题：慢性阻塞性肺疾病 + 二陈汤　；参考：《中国实验方剂学杂志》2017年10期

【摘要】：目的:观察二陈汤加味对慢性阻塞性肺疾病急性加重期(acute exacerbation period of COPD,AECOPD)患者肺功能、细胞和体液免疫功能,细胞趋化因子18(chemoattractant cytokine18,CCL18),白细胞介素-8(interleukin-8,IL-8),Clara细胞蛋白(Clara cell protein,CC16)和可溶性细胞间黏附分子-1(soluble intercellular adhesion molecular-1,s ICAM-1)的影响。方法:选取符合纳入标准的老年AECOPD患者120例,分为治疗组与对照组,每组60例。两组均在常规治疗的基础上,治疗组给予二陈汤加味,每日2次,疗程14 d。14 d后评价两组患者临床疗效,检测肺功能、免疫球蛋白、外周血淋巴细胞亚群,酶联免疫吸附试验(ELISA)测定患者血浆和呼气冷凝液(exhale breath condensat,EBC)中CCL18,CC16,IL-8,s ICAM-1浓度。结果:与对照组治疗后比较,治疗组总有效率高于对照组(P0.05);治疗组1 s用力呼气容积(FEV_1),1 s用力呼气量/用力肺活量(FVC)均增大(P0.01);炎细胞总数、中性粒细胞数、单核细胞和淋巴细胞均减少(P0.05)。与本组治疗前比较,Ig G,Ig A,Ig M无明显差异;CD3~+,CD4~+,CD4~+/CD8~+均增加,CD8~+降低(P0.05);血浆CCL18,CC16,IL-8,s ICAM-1均降低(P0.05),EBC中CCL18,CC16均降低(P0.05)。结论:二陈汤加味可调节T淋巴细胞亚群功能,增强细胞免疫,降低老年AECOPD患者血浆,EBC中CCL18,CC16,IL-8,s ICAM-1水平,对老年AECOPD有一定的抗炎作用。
[Abstract]:Objective: to observe the effects of Erchen decoction on pulmonary function, cellular and humoral immunity in patients with acute exacerbation period of chronic obstructive pulmonary disease (COPD). The effects of chemokine 18(chemoattractant on CCL18P, interleukin-8 (IL-8), Clara cell protein (CC16) and soluble intercellular adhesion molecule-1 intercellular adhesion (ICAM-1) were observed. Methods: 120 elderly patients with AECOPD were divided into treatment group and control group with 60 cases in each group. On the basis of routine treatment, the treatment group was treated with Erchen decoction twice a day. After 14 days of treatment, the clinical efficacy was evaluated, pulmonary function, immunoglobulin and peripheral blood lymphocyte subsets were detected. Enzyme linked immunosorbent assay (Elisa) was used to determine the concentration of CCL18 CC16 / IL-8 ICAM-1 in plasma and exhale breath condensate (EBC). Results: compared with the control group, the total effective rate of the treatment group was higher than that of the control group (P 0.05), the forced expiratory volume of 1 s and FEV / FVCC of the treatment group were all increased, the total number of inflammatory cells, the number of neutrophils, the number of neutrophilic granulocytes in the treatment group were higher than those in the control group. Both monocytes and lymphocytes decreased P0.05. There was no significant difference in plasma CCL18CC16, IL-8s ICAM-1 and the levels of CCL18CC16 / IL-8s ICAM-1 in P0.05, and the levels of CCL18CC16 and CCL18CC16 in EBC were lower than those before treatment. Conclusion: Erchen decoction can regulate the function of T lymphocyte subsets, enhance cellular immunity, decrease the level of CCL18, CC16 and IL-8s ICAM-1 in plasma of elderly AECOPD patients, and have certain anti-inflammatory effect on senile AECOPD.
【作者单位】：河南中医药大学基础医学院;河南医学高等专科学校;河南中医药大学第二附属医院;河南省人民医院;
【基金】：国家自然科学基金面上项目(81573881) 郑州市科技领军人才项目(121PLJRC535) 河南省科技重点攻关项目(152102310337) 河南省高等学校重点科研项目(15A360030) 河南中医学院大学生创新学习项目(CXXM[2016]0019,CXXM[2016]0041) 河南省中医药科学研究专项(2013ZY02070)
【分类号】：R563.9

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