935例老年呼吸道疾病患者非典型病原体检测结果分析

发布时间：2018-05-01 12:42

本文选题：感染 + 呼吸道感染　；参考：《重庆医学》2017年03期

【摘要】：目的探讨泸州地区9种呼吸道非典型病原体在老年呼吸道疾病患者中的病原学流行特点,为临床诊疗提供病原学依据。方法选取2014年7月至2015年6月收治入院的老年呼吸道疾病患者935例,采用间接免疫荧光法检测血清9种呼吸道非典型病原体免疫球蛋白M(IgM)抗体,并对检测结果进行统计分析。结果 935例老年呼吸道疾病患者中,检测出IgM抗体阳性的患者为424例,阳性率为45.3%,同时检测出2种及2种以上病原体混合感染的患者有290例,混合感染率为31.0%,占总感染例数的68.4%,其中嗜肺军团菌(LP)与肺炎支原体(MP)的混合感染在混合感染中所占比例最高为17.9%。所有患者中MP阳性率最高(26.5%),其次为LP(12.1%)、乙型流感病毒(IBV,8.4%)、副流感病毒(PIVs,6.4%)、甲型流感病毒(IAV,5.2%)。慢性支气管炎患者IgM抗体检出率最高为75.9%,慢性阻塞性肺疾病(COPD)伴感染、支气管哮喘伴感染、呼吸道感染、肺炎及肺部感染的老年患者非典型病原体IgM抗体检出率分别为43.9%、43.2%、42.2%、40.3%及38.5%。结论泸州地区老年呼吸道疾病患者非典型病原体感染的主要病原体是MP、LP,混合感染是其显著特点,且不同呼吸道疾病患者间非典型病原体感染具有明显差异。
[Abstract]:Objective to investigate the etiological characteristics of 9 respiratory atypical pathogens in the elderly patients with respiratory tract diseases in Luzhou area, and to provide the etiological basis for clinical diagnosis and treatment. Methods from July 2014 to June 2015, 935 elderly patients with respiratory tract diseases were selected. The serum antibodies against 9 kinds of respiratory atypical pathogens were detected by indirect immunofluorescence assay, and the results were statistically analyzed. Results out of 935 elderly patients with respiratory diseases, 424 patients were positive for IgM antibody, the positive rate was 45.30.290 patients with mixed infection of two or more pathogens were detected at the same time. The mixed infection rate was 31.0 and accounted for 68.4 of the total infection cases. The mixed infection of Legionella pneumophila and Mycoplasma pneumoniae MP) accounted for the highest proportion of 17.9% in the mixed infection. The MP positive rate of all patients was the highest (26.5C), the second was LP12.1, the second was IBV8.4b, the parainfluenza virus (PIVs6.4C), and the influenza A virus (IAV5.2g). The highest detection rate of IgM antibody in chronic bronchitis patients was 75.9%. The detection rate of IgM antibody against atypical pathogens in the elderly patients with chronic obstructive pulmonary disease (COPD), bronchial asthma with infection, respiratory tract infection, pneumonia and pulmonary infection was 43.9% and 38.5%, respectively. Conclusion the main pathogen of atypical pathogen infection in elderly patients with respiratory diseases in Luzhou area is MPLP.The mixed infection is a significant feature and there are significant differences in atypical pathogen infections among patients with different respiratory diseases.
【作者单位】：西南医科大学附属医院输血科;西南医科大学附属医院检验科;
【基金】：四川省卫生厅课题(130534)
【分类号】：R56

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