声动力靶位药物传输辅助治疗复治空洞型肺结核临床观察

发布时间：2018-05-21 17:32

本文选题：复治空洞型肺结核 + 声动力靶位药物传输　；参考：《山东医药》2017年28期

【摘要】：目的探讨声动力靶位药物传输辅助治疗复治空洞型肺结核的临床效果。方法选取复治空洞型肺结核患者146例,随机分为观察组、对照组各73例。两组均采用HRZE标准化疗方案治疗,观察组在此基础上采用声动力靶位药物传输治疗。比较两组治疗6、12个月痰菌转阴率、病灶吸收有效率、空洞闭合有效率,以及治疗12个月内不良反应发生率。结果治疗6个月,观察组痰菌转阴率、病灶吸收有效率、空洞闭合有效率分别为39.27%(29/73)、42.47%(31/73)、43.83%(32/73),对照组分别为21.91%(16/73)、30.14%(22/73)、27.40%(20/73);治疗12个月,观察组痰菌转阴率、病灶吸收有效率、空洞闭合有效率分别为61.64%(45/73)、72.60%(53/73)、71.23%(52/73),对照组分别为50.68%(37/73)、60.27%(44/73)、52.05%(38/73)。观察组治疗6、12个月痰菌转阴率、病灶吸收有效率、空洞闭合有效率均高于对照组(P均0.05)。治疗12个月内,观察组不良反应发生率为13.70%(10/73),对照组为16.44%(12/73),两组比较P0.05。结论在全身化疗的基础上辅以声动力靶位药物传输治疗复治空洞型肺结核能明显提高痰菌转阴率,促进病灶吸收和肺内空洞闭合,且未增加不良反应。
[Abstract]:Objective to investigate the clinical effect of sonodynamic target drug transmission in the treatment of recurrent cavity pulmonary tuberculosis. Methods 146 patients with recurrent cavity pulmonary tuberculosis were randomly divided into observation group (n = 73) and control group (n = 73). Both groups were treated with HRZE standard chemotherapy regimen. The sputum negative rate, the effective rate of focus absorption, the effective rate of cavity closure, and the incidence of adverse reactions within 12 months after treatment were compared between the two groups. Results after 6 months of treatment, the sputum negative rate, the effective rate of focus absorption and the effective rate of cavity closure in the observation group were 39.27% 29 / 73 and 42.4773%, respectively, and 43.833% in the observation group, and 21.91% in the control group, 30.14% in the control group, 27.404.40% 20% 73% in the control group. After 12 months of treatment, the sputum bacteria conversion rate and the focus absorption efficiency were observed in the observation group. The effective rate of cavity closure was 61.64 / 45 / 73 / 72.600.53 / 73 / 71.23 and 52 / 73 / 73, respectively, and that of the control group was 50.68 / 37 / 73 / 60.27 / 52.05, respectively. The sputum negative rate, the effective rate of focus absorption and the effective rate of cavity closure in the observation group were higher than those in the control group (P < 0.05). Within 12 months of treatment, the incidence of adverse reactions in the observation group was 13.70%, and that in the control group was 16.44% (P 0.05). Conclusion on the basis of systemic chemotherapy combined with sonodynamic target drug delivery in the treatment of recurrent cavity pulmonary tuberculosis can significantly improve sputum negative rate promote focus absorption and pulmonary cavity closure and no increase in adverse reactions.
【作者单位】：河北省胸科医院;
【基金】：河北省卫生和计划生育委员会青年科技课题(1020140-039)
【分类号】：R521

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