α-糜蛋白酶联合盐酸氨溴索雾化吸入对AECOPD患者动脉血气指标改善及生活质量的影响

发布时间：2018-07-03 02:10

本文选题：α-糜蛋白酶 + 盐酸氨溴索注射液　；参考：《中国地方病防治杂志》2017年07期

【摘要】：目的探讨α-糜蛋白酶联合盐酸氨溴索注射液雾化吸入对慢性阻塞性肺疾病急性加重期(AECOPD)患者动脉血气指标改善及生活质量的影响。方法 AECOPD患者80例,按治疗方法不同分成观察组和对照组,各40例。对照组采用盐酸氨溴索注射液雾化吸入治疗,观察组采用α-糜蛋白酶联合盐酸氨溴索注射液雾化吸入治疗。比较两组临床疗效、临床观察指标、治疗前后动脉血氧分压(PaO_2)、动脉血二氧化碳分压(Pa CO2)、p H改善情况及生活质量评分(SF-36)。结果治疗前两组PaO_2、Pa CO2、SF-36评分比较差异无统计学意义(P0.05);治疗后观察组总有效率高于对照组(P0.05);患者肺部X线改善时间、肺部Up音消失时间、喘憋消失时间、住院时间少于对照组(P0.05);两组PaO_2、Pa CO2均有所改善,观察组PaO_2高于对照组,Pa CO2低于对照组,p H值高于对照组(P0.05);SF-36评分高于对照组(P0.05)。结论α-糜蛋白酶联合盐酸氨溴索注射液雾化吸入治疗AECOPD患者能提高总有效率,降低肺部X线改善时间、Up音消失时间、喘憋消失时间及住院时间,改善动脉血气指标,提高生活质量。
[Abstract]:Objective to investigate the effect of atomization inhalation of 伪 -chymotrypsin combined with ambroxol hydrochloride injection on the improvement of arterial blood gas index and quality of life in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods 80 patients with AECOPD were divided into observation group and control group. The control group was treated with atomization inhalation of ambroxol hydrochloride injection and the observation group was treated with 伪 -chymotrypsin combined with ambroxol hydrochloride atomization inhalation. The clinical curative effect, clinical observation index, Pao _ 2, Paco _ 2 and SF-36 were compared between the two groups. Results before treatment, there was no significant difference in Pao 2Pa CO 2C SF-36 score between the two groups (P0.05); after treatment, the total effective rate in the observation group was higher than that in the control group (P0.05); The duration of hospitalization was less than that of the control group (P0.05), the Pao _ 2CO _ 2 of the two groups were improved, the Pao _ 2 of the observation group was higher than that of the control group compared with the control group (P0.05) and the SF-36 score of the observation group was higher than that of the control group (P0.05). Conclusion the atomization inhalation of 伪 -chymotrypsin combined with ambroxol hydrochloride injection can improve the total effective rate, reduce the time of lung X-ray improvement, the time of disappearance of breath and hospitalization, and improve the index of arterial blood gas in patients with AECOPD. Improve the quality of life.
【作者单位】：广州中医药大学;深圳市中医院;
【基金】：国家自然科学基金(8177141248)
【分类号】：R563.9

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