头孢哌酮钠舒巴坦钠对反复下呼吸道感染患者中性粒细胞胞外网状陷阱形成的影响
发布时间：2018-08-23 14:08
【摘要】：目的:检测反复下呼吸道感染患者外周血中性粒细胞胞外网状陷阱(NETs)的形成,评价头孢哌酮钠舒巴坦钠对NETs形成的影响。方法:选取反复下呼吸道感染患者36例和健康体检者30名作为病例组和健康对照组。采用激光共聚焦显微镜及扫描电镜检测2组研究对象NETs的形成情况,并根据中性粒细胞的形态将NETs的形成情况分成Ⅰ、Ⅱ和Ⅲ级,计数2组研究对象不同级别NETs形成细胞数量;观察头孢哌酮钠舒巴坦钠处理前后病例组患者NETs的形成情况。结果:病例组患者Ⅰ和Ⅱ级NETs形成细胞数量明显多于健康对照组(P0.05),而Ⅲ级NETs形成细胞数量少于健康对照组(P0.05);头孢哌酮钠舒巴坦钠处理后病例组患者Ⅰ和Ⅱ级NETs形成细胞数量明显少于用药前(P0.05),而Ⅲ级NETs形成细胞数量多于用药前(P0.05)。结论:反复下呼吸道感染患者体内中性粒细胞能形成大量具有高效抗菌功能的NETs,而头孢哌酮钠舒巴坦钠可以抑制NETs的形成。
[Abstract]:Aim: to detect the formation of neutrophil extracellular reticular trap (NETs) in peripheral blood of patients with recurrent lower respiratory tract infection and to evaluate the effect of cefoperazone sodium sulbactam sodium on the formation of NETs. Methods: 36 patients with recurrent lower respiratory tract infection and 30 healthy controls were selected as case group and healthy control group. The formation of NETs was detected by laser confocal microscope and scanning electron microscope. According to the morphology of neutrophils, the formation of NETs was divided into 鈪，
本文编号：2199304
[Abstract]:Aim: to detect the formation of neutrophil extracellular reticular trap (NETs) in peripheral blood of patients with recurrent lower respiratory tract infection and to evaluate the effect of cefoperazone sodium sulbactam sodium on the formation of NETs. Methods: 36 patients with recurrent lower respiratory tract infection and 30 healthy controls were selected as case group and healthy control group. The formation of NETs was detected by laser confocal microscope and scanning electron microscope. According to the morphology of neutrophils, the formation of NETs was divided into 鈪，
本文编号：2199304
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