幽门螺杆菌感染治疗对慢性阻塞性肺疾病患者临床特征的影响

发布时间：2018-08-27 09:05

【摘要】：目的探讨幽门螺杆菌(Hp)感染治疗对慢性阻塞性肺疾病(COPD)患者临床特征的影响,并对比不同治疗方案Hp根除率的差异。方法选取2010年1月-2013年1月收治的98例COPD合并Hp感染患者临床资料,根据治疗方案的不同,分为A组34例、B组34例、C组30例;A及B组均针对Hp感染采取根除治疗,A组采用克拉霉素四联疗法治疗,B组采用莫西沙星四联法治疗;C组患者未采取根除治疗,比较A、B组Hp根除率,记录并比较3组患者治疗前及随访中呼吸功能量表评分(Borg)、肺功能表现、运动承受力、S-Gorge生活质量评分和记录随访期间急性发作次数。结果 A与B组患者Hp根除率分别为50.00%、88.24%,对比差异有统计学意义(P0.05);根除患者治疗后12个月肺功能表现、运动承受力、Borg评分均优于未根除患者,对比差异有统计学意义(P0.05);根除患者治疗12个月后S-Gorge生活质量评分、急性发作次数分别为(33.95±5.88)分、(1.19±0.78)次,均优于未根除患者(43.48±6.12)分、(2.03±0.93)次,对比差异有统计学意义(P0.05)。结论 COPD患者Hp感染根除后,可提升呼吸功能及运动耐受力并降低急性发作发生率,改善生活质量;莫西沙星四联疗法对COPD患者根除Hp临床效果更好,可酌情选用。
[Abstract]:Objective to investigate the effect of Helicobacter pylori (Hp) infection on the clinical characteristics of (COPD) patients with chronic obstructive pulmonary disease (COPD), and to compare the difference of Hp eradication rate between different treatments. Methods the clinical data of 98 patients with COPD complicated with Hp infection from January 2010 to January 2013 were selected. 34 patients in group A, 34 patients in group B, 34 patients in group C, 30 patients in group A and 30 patients in group B were treated with eradication therapy for Hp infection. Group A was treated with clarithromycin combined therapy and group B was treated with moxifloxacin tetralogy. To compare the eradication rate of Hp in group A and B, and to record and compare the respiratory function scale (Borg),) pulmonary function score, the score of S-Gorge quality of life (QOL) and the times of acute attack during follow-up. Results the eradication rate of Hp in group A and group B was 50.000 and 88.24, respectively, the difference was statistically significant (P0.05), the scores of pulmonary function and motor tolerance were better than those of patients without eradication 12 months after eradication treatment. The difference was statistically significant (P0.05), the scores of S-Gorge quality of life after 12 months of eradication treatment were (33.95 卤5.88) and (1.19 卤0.78), respectively, which were better than those of patients without eradication (43.48 卤6.12), (2.03 卤0.93), the difference was statistically significant (P0.05). Conclusion after Hp infection is eradicated in patients with COPD, respiratory function and exercise tolerance can be improved and the incidence of acute attack can be reduced, and the quality of life can be improved by moxifloxacin tetralogy, which is more effective than moxifloxacin in the eradication of Hp in COPD patients.
【作者单位】：山东大学附属临沂市人民医院消化内一科;
【基金】：山东省卫生厅基金资助项目(SW-2010B027)
【分类号】：R563.9

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