网膜素-1与2型糖尿病合并慢性阻塞性肺疾病的关系

发布时间：2018-08-28 10:21

【摘要】：目的探讨血清网膜素-1水平与2型糖尿病并慢性阻塞性肺疾病(COPD)患者的关系。方法选取2型糖尿病合并COPD组,单纯2型糖尿病组和正常对照组共143例患者,测定血清网膜素-1水平,并观察血清网膜素-1与腰臀比、体质指数(BMI)、血糖、血浆胰岛素、血脂的关系,稳态模式评估胰岛素抵抗指数(HOMA-IR)。结果 2型糖尿病合并COPD患者和单纯2型糖尿病患者网膜素-1水平均明显低于对照组(P0.01),血清网膜素-1与HDL-C呈正相关(P0.01)。网膜素-1与BMI、腰臀比、DBP、FPG、TG、HOMAIR、HbA1C呈明显负相关(P0.05或P0.01);多元线性逐步回归分析表明,BMI、DBP、HOMA-IR是影响网膜素-1的因素(P0.05或P0.01)。结论网膜素-1可能涉及了胰岛素抵抗和2型糖尿病合并慢性阻塞性肺疾病患者的发病机制。
[Abstract]:Objective to investigate the relationship between serum omentin-1 level and type 2 diabetes mellitus with chronic obstructive pulmonary disease (COPD). Methods A total of 143 patients with type 2 diabetes mellitus complicated with COPD, simple type 2 diabetes mellitus and normal control group were selected to measure the level of omentin-1 in serum, the ratio of omentin-1 to waist to hip, body mass index (BMI),) blood glucose and plasma insulin. The relationship between blood lipids and homeostasis model for evaluating insulin resistance index (HOMA-IR). Results the levels of omentin-1 in type 2 diabetes mellitus with COPD and simple type 2 diabetes mellitus were significantly lower than those in control group (P0.01). The serum omentin-1 level was positively correlated with HDL-C (P0.01). There was a significant negative correlation between omentin-1 and BMI, WHR (P0.05 or P0.01), and multiple linear stepwise regression analysis showed that HOMA-IR was a factor affecting omentin-1 (P0.05 or P0.01). Conclusion Retinin-1 may be involved in the pathogenesis of insulin resistance and type 2 diabetes with chronic obstructive pulmonary disease.
【作者单位】：广西桂林市人民医院综合内科;
【分类号】：R587.1;R563.9

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