乳腺癌患者化疗后肺部感染与复发转移相关指标的变化研究

发布时间：2018-10-23 20:43

【摘要】：目的探讨乳腺癌患者化疗后肺部感染与复发转移相关指标的变化,为患者治疗干预措施的制定提供依据。方法选取2013年1月-2015年10月45例乳腺癌化疗后肺部感染患者为A组,并选取同时间段内化疗后未发生感染的45例患者为B组,45例单纯肺部感染患者为C组,比较3组患者临床指标,数据采用SPSS 16.0软件进行统计分析。结果 A组患者血清肿瘤标志物包括CA125、CA153、CA199及CEA水平分别为(21.45±2.25)U/ml、(18.51±1.84)U/ml、(19.56±2.24)U/ml及(5.58±0.46)ng/ml,均高于B组及C组;A组的血清VEGF相关指标及MMP相关指标均高于B组及C组,且A组中轻度、中度及重度肺部感染患者的上述血清指标差异均有统计学意义(P0.05)。结论乳腺癌化疗后肺部感染患者复发转移相关指标的变化明显,且肺部感染的严重程度对其血清水平也存在较大的影响,因此应重视对乳腺癌患者化疗后肺部感染的控制。
[Abstract]:Objective to investigate the changes of pulmonary infection, recurrence and metastasis in patients with breast cancer after chemotherapy. Methods from January 2013 to October 2015, 45 patients with pulmonary infection after chemotherapy were selected as group A, 45 patients without infection after chemotherapy in the same period as group B, and 45 patients with simple pulmonary infection as group C. The clinical indexes of the three groups were compared and the data were analyzed by SPSS 16.0 software. Results the levels of serum tumor markers including CA125,CA153,CA199 and CEA in group A were (21.45 卤2.25) U / ml, (18.51 卤1.84) U / ml, (19.56 卤2.24) U/ml and (5.58 卤0.46) ng/ml, higher than those in group B and C, respectively. There were significant differences in the above serum indexes between moderate and severe pulmonary infection patients (P0.05). Conclusion the changes of the relative indexes of recurrence and metastasis in patients with pulmonary infection after chemotherapy are obvious, and the severity of pulmonary infection also has a great influence on the serum level of breast cancer patients. Therefore, we should pay attention to the control of pulmonary infection in patients with breast cancer after chemotherapy.
【作者单位】：河南省人民医院乳腺外科;
【基金】：河南省科技计划基金资助项目(142300410388)
【分类号】：R737.9;R563.1

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