沐舒坦联合多索茶碱对老年慢性支气管炎急性发作患者血清C反应蛋白、白细胞介素-6、肿瘤坏死因子-α水平的影响

发布时间：2018-11-19 20:43

【摘要】：目的探讨沐舒坦联合多索茶碱对慢性支气管炎(CBC)急性期的临床疗效及其在降低老年患者血清C反应蛋白(CRP)、白细胞介素(IL)-6、肿瘤坏死因子(TNF)-α水平的临床应用。方法选取2012年6月至2015年7月该院确诊治疗的CBC急性发作老年患者124例,依据随机分配原则分为联合组和综合组各62例,综合组给予综合基础治疗,联合组在此基础上给予30 mg多索茶碱静脉输液和30 mg沐舒坦静脉注射治疗,采用酶联免疫吸附法(ELISA)检测血清CRP、IL-6、TNF-α水平,统计分析所有患者喘息、咳嗽、湿Up音消失、住院时间和治疗前后最大肺活量(FVC)、1秒用力呼气量(FEV1)、肺功能指数(FEV1/FVC)及不良反应发生情况。结果在喘息、咳嗽、湿Up音消失、住院时间方面,联合组各指标水平明显低于综合组(P0.05);治疗后与综合组对比,联合组血清CRP、IL-6、TNF-α水平明显降低,FVC、FEV1、FEV1/FVC水平明显升高(P0.05);此外,两组患者不良反应发生率分别为8.06%、3.23%,二者对比基本一致(P0.05)。结论沐舒坦联合多索茶碱治疗可有效缓解CBC急性发作老年患者的临床症状,具有改善机体炎症状态和促进肺功能恢复的作用,且具有良好的安全性。
[Abstract]:Objective to investigate the clinical efficacy of ambroxol combined with doxofylline in the treatment of chronic bronchitis at acute stage of (CBC) and its role in reducing serum C-reactive protein (CRP), interleukin-6 (IL) 6) in elderly patients. Clinical application of tumor necrosis factor (TNF)-伪 level. Methods 124 elderly patients with CBC acute attack were selected from June 2012 to July 2015. According to the principle of random distribution, they were divided into two groups: the combined group (62 cases) and the combined group (62 cases). On this basis, the combined group was given 30 mg doxofylline intravenous infusion and 30 mg ambroxol intravenously. The serum CRP,IL-6,TNF- 伪 level was detected by enzyme-linked immunosorbent assay (ELISA), and the wheezing and coughing of all the patients were statistically analyzed. Wet Up sound disappeared, hospitalization time and maximal vital capacity (FVC), 1 second forced expiratory volume (FEV1), pulmonary function index (FEV1/FVC) and adverse reactions occurred before and after treatment. Results in terms of wheezing, cough, disappearance of wet Up sound and hospitalization time, the level of each index in the combined group was significantly lower than that in the combined group (P0.05). Compared with the comprehensive group, the serum CRP,IL-6,TNF- 伪 level and the FVC,FEV1,FEV1/FVC level in the combined group were significantly lower than those in the combined group (P0.05). In addition, the incidence of adverse reactions in the two groups were 8.06 and 3.23, respectively. The comparison between the two groups was basically the same (P0.05). Conclusion ambroxol combined with doxofylline can effectively relieve the clinical symptoms of elderly patients with acute attack of CBC, can improve the inflammatory state and promote the recovery of lung function, and has good safety.
【作者单位】：天津市第五中心医院;
【分类号】：R562.21

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