FAM3基因家族功能研究概况

发布时间：2018-01-08 14:40

本文关键词：FAM3基因家族功能研究概况　出处：《生理科学进展》2013年01期 　论文类型：期刊论文

更多相关文章： FAM基因家族 PANDER 糖尿病 肿瘤

【摘要】：蛋白序列相似度为3的类细胞因子家族(family with similarity 3,FAM3)是2002年发现的新基因家族,其包括四个成员FAM3A、FAM3B、FAM3C和FAM3D。因FAM3B高表达于胰腺胰岛细胞中,又被称为胰腺衍生因子(pancreatic derived factor,PANDER)。PANDER已被证实在胰岛素抵抗和2型糖尿病发展过程中起重要作用,其可能成为2型糖尿病的新干预靶点。FAM3C被发现在胚胎发育和视网膜功能调控,上皮细胞间充质转化及胰腺癌发生过程中起重要作用。FAM3D被发现可能介入了机体能量代谢异常、结肠癌及嗜睡等疾病的发生发展过程。目前尚未见有关FAM3A生物学功能的研究报道。总之,现有研究表明FAM3基因家族成员可能在包括糖尿病和肿瘤在内的多种重大疾病发生发展过程中起重要作用。本综述将对FAM3基因家族的最新研究进展进行简要总结及讨论。
[Abstract]:Protein sequence similarity for cytokine family 3 (family with 3 similarity, FAM3) is a new gene family was found in 2002, including four members of the FAM3A, FAM3B, FAM3C and FAM3D. due to the high expression of FAM3B in pancreatic islet cells, also called pancreatic derived factor (pancreatic derived factor, PANDER.PANDER) proved to play an important role in insulin resistance and type 2 diabetes in the process of development, it may become the target of Xingan pre.FAM3C in type 2 diabetes was found in the regulation of embryonic development and function of the retina, epithelial mesenchymal transition and pancreatic cancer play an important role in.FAM3D were found to be involved in energy metabolism abnormality the occurrence and development of colon cancer and lethargy disease. There is no relevant reports on the biological functions of FAM3A. In conclusion, the current study shows that FAM3 gene family members may include sugar Urine diseases and tumors play an important role in the occurrence and development of many important diseases. This review will briefly summarize and discuss the latest research progress of FAM3 gene family.

【作者单位】：北京大学医学部生理学与病理生理学系北京大学糖尿病中心教育部分子心血管学重点实验室;
【基金】：国家自然科学基金(30870995) 北京市自然科学基金(7122107)资助课题
【分类号】：R363
【正文快照】： 近年来,大量的研究已揭示细胞因子在机体糖脂代谢及能量代谢过程中起重要的调控作用。对一些新发现的细胞因子特别是脂肪细胞因子如瘦素(leptin)、抵抗素(resistin)及脂联素(adiponectin)等的研究已极大地拓展了人们对糖尿病发病机制的认识。目前血清leptin、resistin及adipon

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