恐伤母鼠对仔鼠空间学习及记忆能力影响

发布时间：2018-04-06 23:10

本文选题：恐伤母鼠　切入点：仔鼠　出处：《中国公共卫生》2013年02期

【摘要】：目的探讨恐伤母鼠对仔鼠空间学习和记忆能力影响。方法采用旁观电击法制备恐伤母鼠动物模型,应用Morris水迷宫定位航行实验及空间探索实验测试1月龄仔鼠空间学习和记忆能力。结果定位航行实验中,对照组1～4 d平均潜伏期分别为(47.7±16.7)、(39.8±20.6)、(30.9±18.9)、(26.6±13.3)s,模型组分别为(89.5±27.2)、(70.7±40.0)、(57.4±38.3)、(55.5±35.9)s,模型组比对照组仔鼠平均潜伏期延长,差异均有统计学意义(P0.05);与对照组比较,模型组仔鼠较多采用非有效策略,较少采用有效策略,差异有统计学意义(χ2=5.104,P=0.024);空间探索实验中,模型组比对照组仔鼠平均游泳速度变慢,游泳路程在20%边缘区平均百分比变大,在其他区域平均百分比减小(P0.05)。结论恐伤母鼠可使仔鼠空间学习和记忆能力下降。
[Abstract]:Objective to investigate the effects of fear injury on spatial learning and memory of newborn rats.Methods the female model of fear injury was made by bystander electric shock. The spatial learning and memory abilities of 1-month-old rats were tested by Morris water maze navigation experiment and space exploration experiment.In the spatial exploration experiment, the average swimming speed of the model group was slower than that of the control group, and the average percentage of swimming distance in the 20% edge area was larger than that in the control group, and the difference was statistically significant (蠂 ~ 2 / 5. 104), the average swimming speed of the model group was lower than that of the control group, and the average percentage of swimming distance in the 20% edge area was larger than that in the control group.The average percentage decreased in other regions (P 0.05).Conclusion fear injury can decrease the spatial learning and memory ability of young rats.
【作者单位】：河南中医学院中西医结合基础学科;
【基金】：国家自然科学基金(81072734) 河南省科技创新人才项目(114100510011) 河南省教育厅自然科学基金(2010A360027) 校创新人才项目河南中医学院苗圃工程项目
【分类号】：R-332

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