人体下呼吸道有限元模型及其对气道局部收缩时气体流动的数值模拟

发布时间：2018-04-16 13:35

本文选题：下呼吸道 + 支气管哮喘　；参考：《医用生物力学》2013年S1期

【摘要】：正支气管哮喘(简称哮喘)以气道结构改变和气道对收缩刺激因素的高反应性为病理特征,即气道重塑和气道高反应性。肺气道具有十分复杂的解剖结构,包括各级互异的直径、长度等形态学参数,在正常与病理条件下,气道各级结构还会发生不均匀的收缩和扩张,从而导致气道中复杂的气体流动情况。如何将复杂的气道几何学,气道内流动的气体与变动的气道壁进行耦合,以建立人类呼吸系统的计算生物力学模型和模拟气道内气体的流动和物质传输,如何通过数值模拟方法模拟支气管哮喘时气道重塑和收缩对下呼吸道气流变化的影响等研究具有重要的意义。本研究根据Tawhai下呼吸道模型参数~[1],运用Solidworks软件,建立人类下呼吸道理论模型,将模型结构导
[Abstract]:Positive bronchial asthma (Asthma) is characterized by airway structural changes and airway hyperresponsiveness to systolic stimuli, namely airway remodeling and airway hyperresponsiveness.Lung gas props have very complex anatomical structures, including morphological parameters such as diameters and lengths at different levels. Under normal and pathological conditions, uneven contraction and dilation occur in all levels of airway structures.This leads to complex gas flow in the airways.In order to establish a computational biomechanical model of the human respiratory system and simulate the gas flow and mass transfer in the airway, the complicated airway geometry, the gas flowing in the airway and the changing airway wall are coupled.How to simulate the effects of airway remodeling and contraction on the changes of lower respiratory airflow in bronchial asthma by numerical simulation is of great significance.Based on the parameters of Tawhai lower respiratory tract model and Solidworks software, the theoretical model of human lower respiratory tract was established, and the structure of the model was guided.
【作者单位】：生物流变科学与技术教育部重点实验室重庆大学生物工程学院;常州大学生物医学工程与健康科学研究院;
【基金】：国家自然科学基金(编号:11172340) 重庆市科委百名杰出科技领军人才培养计划高等学校博士学科点专项科研基金(新教师类,20120191120032) 重庆市自然科学基金计划一般项目(Cstc2012jjA0588) 中央高校基本科研业务费(No.CQDXWL-2012-123)资助
【分类号】：R311

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