糖皮质激素与抑郁发病相关机制研究进展

发布时间：2018-06-06 03:56

本文选题：抑郁 + 糖皮质激素　；参考：《中国药理学通报》2013年11期

【摘要】：抑郁症是一种情感障碍性疾病,临床上以兴趣缺乏、情绪低落、睡眠障碍等为主要病症表现,部分患者常伴有自杀倾向。目前研究的抑郁发病机制主要有:单胺假说、神经营养再生假说、神经内分泌假说、表观遗传学假说。近年来的研究发现糖皮质激素和其受体在抑郁的发病机制中起着重要的作用。糖皮质激素是肾上腺分泌的一种激素,在长期应激的作用下,HPA轴持续激活,导致糖皮质激素的持续分泌,引起神经内分泌系统紊乱,在抑郁的发病机制中有重要意义。该文主要针对糖皮质激素及其受体对抑郁发病相关机制的研究进展进行综述。
[Abstract]:Depression is a kind of affective disorder. The main symptoms are lack of interest, depression and sleep disorder. Some patients are often accompanied by suicide. The main mechanisms of depression are monoamine hypothesis, neurotrophic regeneration hypothesis, neuroendocrine hypothesis, epigenetic hypothesis. Glucocorticoid and its receptor play an important role in the pathogenesis of depression. Glucocorticoid is a hormone secreted by the adrenal gland. The HPA axis continues to activate under the action of long-term stress, causing the continuous secretion of glucocorticoid and causing neuroendocrine disorder, which is of great significance in the pathogenesis of depression. This article is mainly concerned with the pathogenesis of depression. The research progress of glucocorticoids and their receptors on depression is reviewed.
【作者单位】：天津中医药大学;中国医学科学院北京协和医学院药物研究所;
【基金】：国家自然科学基金资助项目(No 81274122,81102831) 北京市自然科学基金重点项目(No 7131013) 教育部博士点基金重点项目(No 20121106130001)
【分类号】：R363

【共引文献】