一起肠产毒性大肠杆菌O128:H45引起的院内新生儿腹泻暴发

发布时间：2018-06-19 17:29

本文选题：肠产毒性大肠杆菌 + 大肠杆菌O∶H　；参考：《中国人兽共患病学报》2013年03期

【摘要】：目的探讨一起院内新生儿腹泻暴发的病原及其特征。方法常规方法对可疑腹泻暴发住院新生儿患者粪便、医护人员肛拭子、婴儿奶粉和医院环境标本进行病原分离和鉴定,将分离到的病原菌进行毒力基因检测、药敏试验及PFGE和MLST分子分型分析。结果从12名住院新生儿腹泻患者黄色水样便和1份新生儿ICU病房配奶间的环境标本中分离出13株大肠杆菌O128∶H45和1株大肠杆菌O55,13株大肠杆菌O128∶H45耐热肠毒素基因st均为阳性、具有高度相似性的PFGE带型、MLST的型别均为ST2332型且具有相似的耐药谱。结论首次报道了由肠产毒性大肠杆菌O128∶H45引起的一起院内新生儿腹泻暴发。
[Abstract]:Objective to investigate the pathogen and characteristics of a nosocomial neonatal diarrhea outbreak. Methods the feces of hospitalized neonates with suspected diarrhea outbreak, anal swab of medical staff, infant milk powder and hospital environmental samples were isolated and identified by routine methods. The virulence genes of the isolated pathogens were detected. Drug sensitivity test and molecular typing analysis of PFGE and MLST. Results 13 strains of Escherichia coli O128: H45 and 1 strain of Escherichia coli O58: H45 of 13 strains of Escherichia coli O128: H45 were isolated from yellow water samples of 12 hospitalized neonatal diarrhea patients and an environmental specimen of milk from a neonatal ICU ward. The gene st was positive. The PFGE band type MLST with high similarity was ST2332 and had similar drug resistance spectrum. Conclusion A nosocomial outbreak of neonatal diarrhea caused by enterotoxigenic Escherichia coli O 128: h 45 was reported for the first time.
【作者单位】：四川省自贡市疾病预防控制中心;中国疾病预防控制中心传染病预防控制所传染病预防控制国家重点实验室;
【基金】：国家“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项(No.2011ZX10004-001) 传染病预防控制国家重点实验室开放课题“疑似单增李斯特菌感染患者的病原学监测研究”(No.2012SKLID304)资助~~
【分类号】：R378.2

【参考文献】