血管加压素联合肾上腺素对心室颤动犬模型心肺复苏的作用

发布时间：2018-06-22 05:36

本文选题：血管加压素 + 肾上腺素　；参考：《临床心血管病杂志》2013年08期

【摘要】：目的:评估血管加压素联合应用肾上腺素对心室颤动(室颤)犬模型心肺复苏(CPR)的作用。方法:选取健康杂种犬28只,成功建立室颤模型并给予基本生命支持心肺复苏(BLS-CPR)后,随机分为4组,每组7只。A组首剂应用肾上腺素45μg/kg,B1组首剂应用肾上腺素45μg/kg+血管加压素0.4U/kg,B2组首剂应用肾上腺素45μg/kg+血管加压素0.8U/kg,B3组首剂应用肾上腺素45μg/kg+血管加压素2.4U/kg。4组实验犬应用首剂药物后若未恢复自主循环,以后每3min静脉重复应用首次剂量,共静脉用药3次,期间仍进行持续心肺复苏,以自主循环、心脏停搏或持续室颤作为终点。成功达到自主循环后继续监测30min。结果:在实施BLS-CPR并行电除颤后,A组达到自主循环的仅2只(28.6%),B1组6只(85.7%),B2组和B3组均达到100%,且自主循环所需时间B1组为(74.9±6.52)s,B2组为(71.6±4.89)s,B3组为(70.4±5.66)s,均短于A组[(81.2±6.50)s](均P0.01)。结论:在心肺复苏过程中,血管加压素和肾上腺素联合应用可以显著地增加冠状动脉灌注压,其中血管加压素的剂量以0.8U/kg最适宜。
[Abstract]:Aim: to evaluate the effect of vasopressin combined with epinephrine on cardiopulmonary resuscitation (CPR) in canine models of ventricular fibrillation (VF). Methods: Twenty-eight healthy mongrel dogs were randomly divided into 4 groups after successful establishment of ventricular fibrillation model and basic life support cardiopulmonary resuscitation (BLS-CPR). The first dose of epinephrine 45 渭 g 路kg ~ (-1) B _ (1) was given to 45 渭 g/kg vasopressin 0.4 U / kg B _ (2) in each group. The first dose was 45 渭 g/kg vasopressin 0.8 U / kg B _ (3) with epinephrine 45 渭 g/kg vasopressin 2.4 U / kg / .4 group. If the spontaneous circulation is not restored after the administration of the drug, After that, the first dose of each 3min was repeated for 3 times. During the course of continuous cardiopulmonary resuscitation, the endpoints were autonomic circulation, cardiac arrest or persistent ventricular fibrillation. The monitoring was continued for 30 min after the successful achievement of autonomous circulation. Results: only 2 rats (28.6%) in group A (28.6%) had achieved spontaneous circulation after BLS-CPR and electrical defibrillation, 6 rats (85.7%) in group B _ 1 and B _ (3) were 100, and the time required for spontaneous circulation in group B1 was (74.9 卤6.52) snb _ 2: (71.6 卤4.89) snb _ 3, which was (70.4 卤5.66) s, shorter than that in group A [(81.2 卤6.50) s] (all P 0.01). Conclusion: during cardiopulmonary resuscitation, the combination of vasopressin and epinephrine can significantly increase the coronary artery perfusion pressure, and the best dose of vasopressin is 0.8 U / kg.
【作者单位】：南昌大学第一附属医院干部病房;
【分类号】：R541.75;R-332

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