急、慢性束缚应激对小鼠情绪和学习记忆能力的不同影响

发布时间：2018-06-24 22:46

本文选题：急性束缚应激 + 慢性束缚应激　；参考：《神经解剖学杂志》2013年02期

【摘要】：目的:观察急性束缚应激和慢性束缚应激对小鼠情绪和学习记忆能力的影响。方法:小鼠按体重和自发活动随机分成三组,即空白对照组,急性应激组和慢性应激组。采用束缚躯体的方法建立急慢性应激模型,并用自发活动实验检测小鼠的情绪状态,避暗实验检测小鼠的学习记忆能力。结果:自发活动实验中急性束缚应激组小鼠平均速度与空白组相比有显著增加(P0.01),中央区活动时间和中央区活动路程百分比则显著增加(P0.05),慢性应激组平均速度与空白组相比有显著减小(P0.01),中央区活动时间和中央区活动路程百分比显著减小(P0.05);避暗测试中急性应激组避暗潜伏期和错误次数没有改变,而慢性应激组潜伏期显著减小(P0.05)、错误次数急显著增加(P0.01)。结论:急性束缚应激会使小鼠产生烦躁情绪、但不会改变其学习记忆能力;慢性束缚应激会使小鼠产生抑郁样情绪,会损害其学习记忆能力。
[Abstract]:Aim: to observe the effects of acute restraint stress and chronic restraint stress on emotion and learning and memory ability in mice. Methods: mice were randomly divided into three groups according to body weight and spontaneous activity: blank control group, acute stress group and chronic stress group. The acute and chronic stress model was established by the method of restraining body. The emotional state of mice was detected by spontaneous activity experiment, and the learning and memory ability of mice was detected by avoiding darkness experiment. Results: in the spontaneous activity test, the average speed of mice in the acute restraint stress group was significantly higher than that in the blank group (P0.01), while the activity time in the central area and the percentage of the distance in the central area were significantly increased (P0.05). The mean velocity and empty space in the chronic stress group were significantly higher than those in the control group (P0.01). Compared with the white group, the activity time in the central area and the percentage of the distance in the central area were significantly decreased (P0.01), while the latency and the number of errors in the acute stress group did not change in the dark avoidance test. The latency of chronic stress group decreased significantly (P0.05), the number of errors increased significantly (P0.01). Conclusion: acute restraint stress can induce irritable emotion in mice, but it will not change its ability of learning and memory, and chronic restraint stress will cause depression and damage its ability of learning and memory.
【作者单位】：中国药科大学中药复方研究室;福建医科大学;第四军医大学;
【基金】：国家自然科学基金(30873322) 天然药物活性组分与药效国家重点实验室资助项目(SKLNMKF201214)
【分类号】：R363

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