丹红注射液对急性脑梗塞后外周血中VEGF水平影响的相关研究

发布时间：2018-01-02 09:18

本文关键词：丹红注射液对急性脑梗塞后外周血中VEGF水平影响的相关研究　出处：《吉林大学》2014年硕士论文　论文类型：学位论文

【摘要】：目的：通过丹红注射液对急性脑梗塞患者的治疗研究，从血管新生角度，探讨丹红注射液对血管内皮生长因子（VEGF）的作用。方法：随机选择在本院住院治疗的急性脑梗塞患者60例，全部病例均符合1995年第四届全国脑血管病会议制定的急性脑梗塞的诊断标准，并经脑CT或MRI检查证实。将入选病例分为丹红治疗组及对照组，分别在入院第2天和治疗12天后采静脉血，使用酶联免疫吸附法检测血浆中VEGF的变化，探讨丹红对血管内皮生长因子（VEGF）的作用水平。结果：对照组及治疗组治疗后VEGF水平均较治疗前VEGF水平升高，差别有统计学意义（P＜0.05）；且丹红治疗组VEGF水平较对照组升高明显，差别有统计学意义（P＜0.05）。结论： 1.脑梗塞患者急性期体内血管内皮生长因子水平呈增高趋势。2.丹红注射液能够增加急性脑梗塞患者外周血中血管内皮生长因子的水平。3.从血管新生角度，，支持丹红注射液对脑梗塞治疗作用。
[Abstract]:Objective: The effect of Danhong injection on vascular endothelial growth factor (VEGF) in patients with acute cerebral infarction was studied from the point of view of angiogenesis. Methods: Sixty patients with acute cerebral infarction who were hospitalized in our hospital were randomly selected, all of whom were in accordance with the diagnostic criteria of acute cerebral infarction established by the 4th National Conference on Cerebrovascular Disease in 1995. The patients were divided into two groups: Danhong treatment group and control group. Venous blood was collected on the second day of admission and 12 days after treatment. The changes of VEGF in plasma were detected by enzyme-linked immunosorbent assay (Elisa) to investigate the effect of Danhong on vascular endothelial growth factor (VEGF). Results: The level of VEGF in control group and treatment group was higher than that before treatment (P < 0.05). The level of VEGF in Danhong treatment group was significantly higher than that in control group (P < 0.05). Conclusion: 1. The level of vascular endothelial growth factor (VEGF) in patients with acute cerebral infarction is increasing in the acute phase. 2. Danhong injection can increase the level of vascular endothelial growth factor in peripheral blood of patients with acute cerebral infarction. Angle. Effect of supporting Danhong injection on cerebral infarction.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R743.33

【参考文献】