长期亚低温对比短期亚低温治疗重型颅脑损伤的系统评价

发布时间：2018-01-04 00:21

本文关键词：长期亚低温对比短期亚低温治疗重型颅脑损伤的系统评价　出处：《医学研究生学报》2014年11期 　论文类型：期刊论文

【摘要】：目的亚低温技术对重型颅脑损伤的脑保护作用与预后改善有着广泛的认可。文中分析长期亚低温与短期亚低温治疗对重型颅脑损伤患者预后的影响及并发症的情况。方法按Cochrane系统评价方法,全面检索Cochrane协作网、Pubmed、Embase、CBM、CNKI、万方、维普各数据库对纳入文献的质量进行评估,提取数据后运用Rev Man 5.2软件进行Meta分析。结果亚低温治疗长期组相对于短期组改善了预后(格拉斯哥预后评分4~5分)[RR=1.37,95%CI(1.14,1.64)],差异有统计学意义(P=0.0006);而在肺炎发生率、心律失常发生率以及应激性溃疡发生率等方向,差异均无统计学意义(P0.05)。结论长期亚低温治疗较短期亚低温治疗对重型颅脑损伤患者的预后有改善作用,没有明显增加肺炎、心律失常、应激性溃疡的发生率。
[Abstract]:Objective to evaluate the effect of mild hypothermia on brain protection and prognosis improvement in patients with severe craniocerebral injury. The effects of long-term mild hypothermia and short-term mild hypothermia on the prognosis of patients with severe craniocerebral injury and their complications were analyzed in this paper. Methods according to Cochrane system evaluation method. To evaluate the quality of the literature involved in the comprehensive search of the Cochrane collaboration network, Cochrane Cochrane EmbaseCBI, Wannfang and Weip databases. Rev Man 5.2 software was used for Meta analysis. Results the prognosis was improved in the long-term mild hypothermia group compared with the short-term group (Glasgow prognosis score 4 ~ 5 points). [The difference was statistically significant (P < 0.0006). But in the incidence of pneumonia, arrhythmia and stress ulcer incidence and other directions. Conclusion the long-term mild hypothermia therapy can improve the prognosis of the patients with severe craniocerebral injury compared with the short-term mild hypothermia treatment, and has no significant increase in pneumonia and arrhythmia. Incidence of stress ulcer.
【作者单位】：河北联合大学附属医院神经外科;河北联合大学;河北联合大学附属医院重症医学科;
【基金】：唐山市卫生临床技术研究计划课题(10150204A-20)
【分类号】：R651.15
【正文快照】： 0引言亚低温治疗颅脑损伤可能的作用机制包括降低血脑屏障和血管壁的通透性、减轻脑水肿、减轻细胞内酸中毒、减少自由基的产生、抑制免疫应答和有害的炎症反应、降低能量和氧的代谢率[1-2]。亚低温技术对重型颅脑损伤的脑保护作用和改善预后已得到大多数研究者的认可,并广泛

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