急性心力衰竭患者联合检测血清糖类抗原CA125和N末端脑钠肽原的临床意义

发布时间：2018-01-31 06:48

本文关键词： 急性心力衰竭 CA NT-proBNP 预后死亡率　出处：《中国现代医学杂志》2016年24期 　论文类型：期刊论文

【摘要】：目的对联合检测血清糖类抗原CA125(CA125)和N末端脑钠肽原(NT-proBNP)水平用于预测急性心力衰竭患者预后的价值进行评估。方法纳入68例急性左心衰竭发作24 h之内入院的患者,检测血清NT-proBNP和CA125水平,根据患者出院6个月时的预后,分为死亡(6个月之内死亡)、再发作(存活,有急性左心衰竭再发作)和稳定(存活且无心力衰竭再发作)组,对单独和联合应用NT-proBNP和CA125水平用于预测患者预后的价值进行分析。结果不同分组患者的CA125水平差异有统计学意义(P=0.013),再发作组和死亡组患者的血清CA125水平高于稳定组,差异有统计学意义(P=0.004和0.030),CA125和NT-proBNP均为阳性者的死亡风险高于其他患者。结论联合检测血清CA125和NT-proBNP水平,可以准确预测急性心力衰竭患者出院6个月之内的死亡风险。
[Abstract]:Objective to detect serum carbohydrate antigen CA125 (CA125) and N-terminal brain natriuretic peptide (NT-proBNPs). Methods 68 patients with acute left heart failure were admitted within 24 hours. The serum levels of NT-proBNP and CA125 were measured. According to the prognosis of the patient at 6 months after discharge, the patients were divided into death (death within 6 months, reattack) (survival). The group with acute left ventricular failure (ARF) and stable (survival with no recurrence of heart failure). The value of NT-proBNP and CA125 levels in predicting the prognosis of patients was analyzed. Results there were significant differences in CA125 levels among different groups of patients (. P0. 013). The serum CA125 levels in patients with recurrent attack and death were significantly higher than those in stable group (P 0. 004 and 0. 030). The risk of death in both CA125 and NT-proBNP positive patients was higher than that in other patients. Conclusion Serum CA125 and NT-proBNP levels are detected in combination. It can accurately predict the risk of death in patients with acute heart failure within 6 months of discharge.
【作者单位】：北京大学国际医院;首都医科大学宣武医院;
【分类号】：R541.6
【正文快照】： 研究表明,糖类抗原CA125(carbohydrate anti-gen-125,CA125)除了作为临床诊断卵巢癌的标志性抗原之外,还可作为心功能不全及心脏移植患者血流动力学和心功能改变的指标[1],急性心力衰竭发表3 CA125、NT-pro BNP不同组患者的死亡风险组别例数死亡/存活/例死亡率/%CA125阳性NT-p

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