神经节苷脂治疗重型颅脑损伤患者效果及对血清炎症指标和神经元特异性烯醇化酶水平的影响

发布时间：2018-02-04 00:11

本文关键词： 血清炎症指标神经节苷脂颅脑损伤　出处：《中国老年学杂志》2016年17期 　论文类型：期刊论文

【摘要】：目的探讨神经节苷脂治疗重型颅脑损伤(s TBI)患者的疗效及对血清炎症指标和血清神经元特异性烯醇化酶(NSE)水平的影响。方法 98例s TBI患者采用随机分层法分为对照组(n=49,采用降颅压、抗感染、亚低温等常规治疗)和观察组(n=49,在上述基础上联合神经节苷脂静滴),观察两组超敏C反应蛋白(hs-CRP)、白介素(IL)-6、肿瘤坏死因子(TNF)-α等血清炎症指标和NSE水平的变化,观察随访治疗2个月后的疗效差异。结果两组治疗前hs-CRP、IL-6、TNF-α等血清炎症指标和NSE水平比较无显著性差异(P0.05);治疗14 d后,观察组hs-CRP、IL-6、TNF-α、NSE水平明显低于对照组(P0.05)。观察组治疗2个月后有效率明显高于对照组(P0.05)。两组并发症发生率和药物不良反应比较无统计学差异(P0.05)。结论神经节苷脂治疗s TBI疗效显著且安全性高,作用机制可能与降低血清炎症指标和NSE水平密切相关。
[Abstract]:Objective to investigate the therapeutic effect of ganglioside on patients with severe craniocerebral injury (TBI) and its effect on serum inflammatory indexes and serum neuron-specific enolase (NSE). Methods 98 patients with TBI were randomly divided into control group (n = 98) and control group (n = 49). Two groups of hypersensitive C-reactive protein (hs-CRP) were observed on the basis of lowering intracranial pressure, anti-infection and mild hypothermia. The changes of serum inflammatory indexes and NSE levels such as interleukin-6, tumor necrosis factor TNF- 伪, and so on, were observed after 2 months of follow-up treatment. Results hs-CRP was observed before treatment in the two groups. There was no significant difference in the levels of serum inflammatory markers and NSE between IL-6 and TNF- 伪. After 14 days of treatment, hs-CRP IL-6 and TNF- 伪 were observed in the observation group. The level of NSE was significantly lower than that of the control group (P 0.05). The effective rate of the observation group was significantly higher than that of the control group after 2 months of treatment (P 0.05). There was no significant difference in the incidence of complications and adverse drug reactions between the two groups (P 0.05). Conclusion ganglioside is effective and safe in the treatment of s TBI. The mechanism may be closely related to the reduction of serum inflammatory markers and NSE levels.
【作者单位】：福建省第二人民医院急诊外科;
【分类号】：R651.15
【正文快照】： 我国重型颅脑损伤(s TBI)的发病率占颅脑损伤的20%左右,是导致患者死亡、残疾的重要原因〔1〕。因此,有效降低s TBI患者脑细胞凋亡,保护与修复受损脑细胞,降低死亡、致残率,是目前临床治疗s TBI的关键。神经节苷脂是含唾液酸的糖神经鞘脂,是神经细胞膜的组成成分,在神经发生、

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