ICU患者鲍氏不动杆菌感染及治疗研究

发布时间：2018-02-04 08:19

本文关键词： 鲍氏不动杆菌多药耐药感染定植抗菌药物治疗　出处：《中华医院感染学杂志》2016年21期 　论文类型：期刊论文

【摘要】：目的调查医院脑外科重症监护病房(NICU)和重症医学科(ICU)患者鲍氏不动杆菌定植及感染的发生率,以及治疗和转归情况;总结鲍氏不动杆菌感染的临床治疗经验,探讨鲍氏不动杆菌感染的治疗方法。方法收集2013年9月-2015年2月医院重症监护病房病原学诊断为鲍氏不动杆菌定植/感染68例患者的临床资料,统计该菌的耐药情况、定植及感染率、感染组的治疗方法和转归,记录结果并进行统计学分析。结果 68例菌株中,其中定植44株占64.22%,全部为痰标本;24株感染占35.78%,标本主要为下呼吸道30株;本研究中下呼吸道感染B组总有效率为77.78%;A组总有效率为88.89%;A组及B组临床有效率经过统计学检验后差异无统计学意义。结论检出菌株多药耐药非常严重,定植菌株全部来自呼吸道,感染菌株也多以下呼吸道为主,但是亦分布于血液系统、泌尿系统、腹腔引流液、颅内等其他部位;鲍氏不动杆菌下呼吸道感染患者,使用抗菌药物组的临床有效率并不优于停用抗菌药物组的临床有效率。
[Abstract]:Objective to investigate the incidence, treatment and outcome of Acinetobacter baumannii colonization and infection in patients in intensive care unit (NICU) and intensive care unit (ICU). To summarize the experience of clinical treatment of Acinetobacter baumannii infection. To explore the treatment of Acinetobacter baumannii infection. The clinical data of 68 patients with Acinetobacter baumannii colonization / infection from September 2013 to February 2015 were collected. Statistics of drug resistance, colonization and infection rate, treatment methods and outcome of infection group, record and statistical analysis. Results among 68 strains, 44 strains accounted for 64.22%. All sputum specimens; 24 strains of infection accounted for 35.78 strains, and 30 strains of lower respiratory tract were mainly collected. In this study, the total effective rate of lower respiratory tract infection group B was 77.78; The total effective rate of group A was 88.89; There was no significant difference in the clinical effective rate between group A and group B. ConclusionThe multidrug resistance of the strains detected was very serious, all the colonized strains came from the respiratory tract, and most of the infected strains were lower respiratory tract. But also distributed in the blood system, urinary system, abdominal drainage fluid, intracranial and other parts; In patients with lower respiratory tract infection of Acinetobacter baumannii, the clinical effective rate of antibiotic group was not better than that of stop antibiotics group.
【作者单位】：常州市肿瘤医院院感办;
【分类号】：R378
【正文快照】： 不动杆菌属为一群不发酵糖类、氧化酶阴性、不能运动的革兰阴性杆菌,在不动杆菌属中感染率最高的是鲍氏不动杆菌(Acinetobacter baumannii)[1-3]。自20世纪70年代以来,有关多药耐药鲍氏不动杆菌(MDRAb)的文献报道越来越多,多药耐药鲍氏不动杆菌经常发生于住院的危重患者中,是

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