白细胞介素-17在脓毒症患者中表达及其临床意义研究

发布时间：2018-02-04 18:07

本文关键词： 白细胞介素- 脓毒症降钙素原　出处：《中华医院感染学杂志》2016年22期 　论文类型：期刊论文

【摘要】：目的观察白细胞介素-17(IL-17)在脓毒症患者中的表达,探讨其与疾病严重程度的相关性,为临床诊治提供参考依据。方法收集2015年1月-12月住院72例脓毒症患者,根据感染严重程度分为脓毒症组(20例)、严重脓毒症组(24例)及脓毒症休克组(28例),患者入院24小时及治疗后7天分别应用ELISA检测白介素-17、降钙素原及白三烯B4水平,并与健康对照组比较。结果健康对照组、脓毒症组、严重脓毒症组及脓毒症休克组患者血IL-17检测结果分别是:21.58±4.89,23.95±7.10,43.84±13.28,75.31±23.04,四组差异有统计学意义(t=87.8687,P0.05);脓毒症组、严重脓毒症组及脓毒症休克组血IL-17治疗前、后的水平分别是:(38.64±11.65)VS(21.25±5.64),(t=4.2667,P0.05);(44.65±12.89)VS(26.45±6.87),(t=3.5204,P0.05);(76.32±22.53)VS(34.54±13.46),(t=2.8018,P0.05);差异均有统计学意义。结论 IL-17与脓毒症的严重程度呈正相关,是预测脓毒症患者死亡率的重要因子。
[Abstract]:Objective To observe the effect of interleukin -17 (IL-17) expression in patients with sepsis, and explore its correlation with the severity of the disease, to provide reference for clinical diagnosis and treatment. Methods -12 months of January 2015 72 cases of hospitalized patients with sepsis, according to the severity of infection were divided into sepsis group (20 cases), severe sepsis group (24 cases) and septic shock group (28 cases), patients admitted to hospital 24 hours and 7 days after treatment were detected by ELISA and interleukin -17, procalcitonin and leukotriene B4 level, and compared with healthy control group. Results in healthy control group, sepsis group, severe sepsis sepsis group and septic shock group IL-17 blood test results are: 21.58 + 4.89,23.95 + 7.10,43.84 + 13.28,75.31 + 23.04, there was significant difference between four groups (t=87.8687, P0.05); sepsis group, severe sepsis group and septic shock group blood IL-17 before treatment, after the level respectively. Is (38.64 + 11. 65) VS (21.25 + 5.64), (t=4.2667, P0.05); (44.65 + 12.89) VS (26.45 + 6.87), (t=3.5204, P0.05); (76.32 + 22.53) VS (34.54 + 13.46), (t=2.8018, P0.05); the differences were statistically significant. Conclusion IL-17 and severe sepsis the degree of positive correlation is an important factor in predicting mortality in patients with sepsis.

【作者单位】：承德市中心医院感染性疾病科;承德市中心医院重症医学科;
【基金】：河北省科技计划支援项目(11276103D-45)
【分类号】：R459.7
【正文快照】： 脓毒症是由感染引起的全身炎症反应综合征,可发展为严重脓毒症和脓毒症休克。脓毒症病情凶险,病死率高,且治疗花费高,医疗资源消耗大。在疾病早期对脓毒症治疗效果及预后进行评测是目前医学研究的热点之一[1]。多项研究显示脓毒症发病的本质是机体过度释放的炎症介质引起免疫

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