热毒宁注射液用于脓毒症致ARDS患者效果观察

发布时间：2018-02-05 04:58

  本文关键词： 脓毒症 急性呼吸窘迫综合征 机械通气 热毒宁注射液 临床疗效　出处：《山东医药》2016年12期 　论文类型：期刊论文

【摘要】：目的探讨热毒宁注射液对脓毒症致急性呼吸窘迫综合征(ARDS)的治疗效果。方法将ICU住院治疗的脓毒症致ARDS患者58例随机分为观察组、对照组各29例,两组均给予机械通气及其他临床基础治疗;观察组在此基础上静滴热毒宁注射液20 m L,1次/d;两组疗程均为10 d。治疗前后分别采集两组外周血,进行白细胞(WBC)计数;检测血清CRP、降钙素原(PCT);检测PaO_2、Pa CO2,计算氧合指数(PaO_2/FiO_2)。两组治疗前后分别进行APACHEⅡ评分。比较两组撤机成功率、ICU病死率、ICU住院时间及不良反应。结果两组治疗后PaO_2、PaO_2/FiO_2均较治疗前增加,Pa CO2、WBC计数及血清CRP、PCT、APACHEⅡ评分均较治疗前降低,但观察组上述改变更显著(P均0.05)。观察组ICU病死率及ICU住院时间、撤机时间均低于对照组,撤机成功率高于对照组,两组比较P均0.05。两组均未见明显不良反应。结论热毒宁注射液治疗脓毒症致ARDS的临床效果较好。
[Abstract]:Objective to investigate the therapeutic effect of Reduning injection on acute respiratory distress syndrome (ARDS) caused by sepsis. Methods 58 patients with ARDS caused by sepsis who were hospitalized with ICU were randomly divided into observation group. In the control group, 29 cases were treated with mechanical ventilation and other basic clinical treatment. On the basis of this, the observation group received intravenous drip of 20 mL of RDNI for one time per day; The course of treatment in both groups was 10 days. The peripheral blood was collected before and after treatment for WBCcount. Serum CRP and procalcitonin PCT were detected. PaO _ 2 / Pa CO _ 2 was measured, and the oxygen index was calculated. The two groups were scored with APACHE 鈪，

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