艾司西酞普兰联合奥扎格雷钠治疗老年急性脑梗死合并焦虑抑郁障碍患者的临床观察

发布时间：2018-02-09 23:36

本文关键词： 艾司西酞普兰奥扎格雷钠急性脑梗死焦虑抑郁　出处：《中国药房》2016年26期 　论文类型：期刊论文

【摘要】：目的:观察艾司西酞普兰联合奥扎格雷钠治疗老年急性脑梗死合并焦虑抑郁障碍患者的临床疗效及安全性。方法:选择老年急性脑梗死合并焦虑抑郁障碍患者140例,按随机数表法分为对照组和观察组,各70例。对照组患者采用常规治疗,并给予注射用奥扎格雷钠40~80 mg加入0.9%氯化钠注射500 ml中,ivgtt,bid;观察组患者在对照组基础上加服草酸艾司西酞普兰片10 mg,qd。两组患者均治疗8周。比较两组患者治疗前后汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)、美国国立卫生院脑卒中量表(NIHSS)评分及Barthel(BI)指数,并观察临床疗效及不良反应发生情况。结果:两组患者治疗前HAMA、HAMD、NIHSS、BI指数及治疗1周后NIHSS、BI指数比较,差异均无统计学意义(P0.05);观察组患者治疗1、4、8周后HAMA、HAMD评分及治疗4、8周后NIHSS、BI指数显著改善,对照组患者治疗4、8周后上述指标显著改善,且观察组改善程度显著优于对照组,差异均有统计学意义(P0.05)。观察组患者临床总有效率为87.14%,显著高于对照组的74.29%,差异有统计学意义(P0.05)。两组患者不良反应发生率比较,差异无统计学意义(P0.05)。结论:艾司西酞普兰联合奥扎格雷钠治疗老年急性脑梗死合并焦虑抑郁障碍患者的疗效显著,能明显改善患者的焦虑抑郁状态和神经功能,且安全性较好。
[Abstract]:Objective: to observe the clinical efficacy and safety of Escitalopram combined with ozagrel sodium in the treatment of elderly patients with acute cerebral infarction complicated with anxiety and depression. Methods: 140 elderly patients with acute cerebral infarction complicated with anxiety and depression were selected. The patients in the control group were divided into two groups, the control group and the observation group with 70 cases each. The patients in the control group were treated with routine therapy. Ozagrel sodium 4080mg plus 0.9% sodium chloride was injected into 500ml iv gttbidin. The patients in the observation group were treated with 10 mg estalopram oxalate on the basis of the control group. The two groups were treated for 8 weeks. The two groups were compared before and after treatment. Hamilton anxiety scale (Hamilton anxiety scale), Hamilton Depression scale (Hamd), National Institutes of Health (NHS) Stroke scale (NIHSS) and Barthelberg Index (BI); The clinical efficacy and adverse reactions were observed. Results: the index of HAMA-HAMD-NIHSSBI before treatment and the index of NIHSSBI after one week of treatment were compared between the two groups. The scores of Hama Hamd and NIHSSBI index in the observation group were significantly improved after 48 weeks of treatment, and those in the control group were significantly improved after 48 weeks of treatment, and the degree of improvement in the observation group was significantly better than that in the control group. The total clinical effective rate in the observation group was 87.14, which was significantly higher than that in the control group (74.29), and the difference was statistically significant (P 0.05). Conclusion: the efficacy of Escitalopram combined with ozagrel sodium in the treatment of elderly patients with acute cerebral infarction combined with anxiety and depression disorder is significant, and it can obviously improve the anxiety and depression state and neurological function of the patients, and the safety is good.
【作者单位】：武汉市普仁医院神经内科;
【分类号】：R971

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