中药升降散干预脓毒症免疫功能紊乱的临床疗效及其可能机制探讨

发布时间：2018-02-12 11:33

本文关键词： 脓毒症免疫功能升降散临床疗效　出处：《免疫学杂志》2017年11期 　论文类型：期刊论文

【摘要】：目的评估中药升降散对纠正脓毒症免疫功能紊乱和改善患者症状的临床疗效。方法选取2014年6月至2016年6月在宁夏回族自治区工人医院就诊的53例脓毒症患者作为研究对象,根据住院号的奇偶性分为观察组(n=28)和对照组(n=25)。2组均予以西医常规治疗,观察组在此基础上加用升降散治疗,对照组则相应给予生理盐水。观察2组在治疗后第1、3和7天的免疫指标变化和记录28天内的临床结局。结果与对照组相比,观察组患者在给药第7天时的CD4~+T细胞计数、CD8~+T细胞计数和m HLADR表达显著增加(P0.05)。进一步评估单核细胞功能结果显示,与对照组相比,观察组患者在给药第3天和第7天的单核细胞分泌的IL-6和TNF-α水平显著提高(P0.05),而在第7天的IL-10水平显著降低(P0.05)。观察组患者的ICU住院时间、APACHE II评分、Marshall评分和血管加压素使用时间均显著低于对照组(P0.05)。结论升降散可以纠正脓毒症患者的细胞免疫,并且可作为一个有希望的脓毒症辅助治疗方案。
[Abstract]:Objective to evaluate the clinical effect of Shengsheng Powder on correcting the immune dysfunction and improving the symptoms of sepsis. Methods 53 patients with sepsis were selected from June 2014 to June 2016 in the workers' hospital of Ningxia Hui Autonomous region. According to the parity of hospital number, the patients in the observation group were divided into two groups: the observation group and the control group were treated with routine western medicine. The control group was given normal saline accordingly. The changes of immune indexes and clinical outcome within 28 days after treatment were observed and compared with those in the control group. The CD4 ~ T cell count and the expression of m HLADR were significantly increased in the observation group on the 7th day after administration. Further evaluation of monocyte function showed that compared with the control group, the expression of m HLADR and CD8T cell were significantly increased in the observation group. The levels of IL-6 and TNF- 伪 secreted by monocytes on the 3rd and 7th day of administration in the observation group were significantly higher than those in the control group, while the level of IL-10 was significantly decreased on the 7th day. The ICU hospitalization time of the patients in the observation group was evaluated by Apache II score and vascular pressure. Conclusion Shengsheng Powder can correct the cellular immunity of sepsis patients. It can be used as a promising adjuvant therapy for sepsis.
【作者单位】：宁夏回族自治区工人疗养院普外科;天津市人民医院科普外科;
【分类号】：R459.7

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