血清透明质酸水平预测急性期自发性脑出血患者预后的临床研究

发布时间：2018-02-13 23:51

本文关键词： 透明质酸脑出血预后　出处：《国际神经病学神经外科学杂志》2017年02期 　论文类型：期刊论文

【摘要】：目的探讨血清透明质酸(HA)在急性自发性脑出血(ICH)发作后的变化及与ICH患者预后的关系。方法前瞻性收集284例自发性ICH患者为研究对象,记录一般资料、病史、临床资料以及影像学特点等指标;另外收集95例年龄和性别相匹配的健康人作为对照组进行对比分析。采用改良的Rankin量表对患者出院后90 d时情况进行评分,根据评分将患者分为预后良好组和预后不良组,对两组患者进行统计分析。结果 ICH患者血清HA水平高于对照组,差异具有统计学意义(P0.001)。284例患者中211例患者预后良好,73例患者预后不良;预后不良组患者HA水平(796.1±49.6 ng/mL),明显高于预后良好组的(487.2±42.9 ng/ml),两组比较差异具有统计学意义(P0.001)。患者HA水平与入院时的NIHSS评分呈正相关关系(r~2=0.372,P0.001);与治疗后90 d的mRS评分呈正相关关系(r~2=0.456,P0.001)。结论在急性自发性ICH患者中,HA表达水平明显升高,且入院时高血清HA水平是预后不良的预测因素。
[Abstract]:Objective to investigate the changes of serum hyaluronic acid (HA) after acute spontaneous intracerebral hemorrhage (ICH) and its relationship with the prognosis of patients with ICH. The clinical data and imaging features were compared and analyzed with 95 healthy persons matched for age and sex as control group. The modified Rankin scale was used to evaluate the condition of the patients at 90 days after discharge from hospital. According to the score, the patients were divided into good prognosis group and poor prognosis group, the two groups were statistically analyzed. Results the serum HA level of ICH patients was higher than that of control group. The difference was statistically significant in 211 patients with good prognosis and 73 patients with poor prognosis. The HA level in the poor prognosis group was 796.1 卤49.6 ng / mL, which was significantly higher than that in the good prognosis group (487.2 卤42.9 ng / ml). The difference between the two groups was statistically significant (P 0.001). There was a positive correlation between the HA level and the NIHSS score on admission, and a positive correlation with the mRS score 90 days after treatment. Conclusion the level of HA expression in patients with acute spontaneous ICH is significantly higher than that in patients with acute spontaneous ICH. High serum HA level at admission was a predictor of poor prognosis.
【作者单位】：衡水市哈励逊国际和平医院神经内科;
【分类号】：R743.34

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