基于OCT图像的组织散射系数提取方法及其应用

发布时间：2018-02-15 13:20

本文关键词： 光学相干层析成像散射系数皮肤疮面量化　出处：《华南师范大学学报(自然科学版)》2016年04期 　论文类型：期刊论文

【摘要】：采用自制频域光学相干层析(OCT)系统对大鼠的正常和疮伤皮肤进行成像,轴向分辨率为8μm,探测深度3 mm,根据组织对光的吸收特性和OCT成像系统的共聚焦特性,建立了A-scan方向图像灰度随探测深度的单次散射-点扩散函数模型.利用模型中的散射系数作为量化皮肤疮面诊断的光学评价指标.测量了正常与疮伤皮肤在各阶段的皮肤衰减系数,证明衰减系数能够定量区分正常与疮伤皮肤.
[Abstract]:A frequency domain optical coherence tomography (Oct) system was developed for the imaging of normal and sore skin in rats. The axial resolution was 8 渭 m and the depth of detection was 3 mm. According to the light absorption characteristics of the tissue and the confocal characteristics of the OCT imaging system, the axial resolution was 8 渭 m and the depth of detection was 3 mm. A single scattering point diffusion function model of A-scan directional image with detection depth is established. The scattering coefficient of the model is used as the optical evaluation index for quantifying the diagnosis of skin sore surface. The normal skin and sore skin are measured in each order. The skin attenuation coefficient of the segment, It is proved that attenuation coefficient can quantitatively distinguish normal skin from sore skin.
【作者单位】：华南师范大学物理与电信工程学院;清华大学深圳研究生院生物医学工程研究所;
【基金】：国家自然科学基金项目(61378089;81571837)
【分类号】：TP391.41;R641

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