急性脑出血患者不同炎症因子与周围脑组织水肿的相关性分析

发布时间：2018-02-22 05:05

本文关键词： 脑出血炎症细胞因子脑水肿白细胞介素相关性　出处：《新乡医学院》2013年硕士论文　论文类型：学位论文

【摘要】：背景随着近年来国内外学者的深入研究发现,炎症细胞因子白细胞介素-1、白细胞介素-2、白细胞介素-4、白细胞介素-6、白细胞介素-8、白细胞介素-10、白细胞介素-18以及TNF-α等均是介导脑出血之后脑水肿形成的重要炎症因子。虽然大量的实验与研究结果均已全面证实以上各种炎症因子在脑出血的急性期均不同程度地参与血肿周围脑组织水肿的发生,同时,各炎症因子之间还存在着彼此促进、调节以及抵制的作用,但是,对于各炎症因子与血肿周围组织的相关性哪种炎症因子发挥的作用、参与的程度更多、更密切、更具代表性则尚无更多的报道。因此,将通过本实验对相关炎症因子与血肿周围脑组织的相关性进行研究与分析。目的测定脑出血患者脑血肿液和血清中的白细胞介素-4、白细胞介素-6、白细胞介素-8、白细胞介素-10的水平,探索脑水肿的发生机制；各炎症因子水平与脑水肿的关系以及彼此间的相关性；并对炎症因子与脑水肿的相关性以及具有代表性的炎症因子做出进一步的明确分析,为将来的临床治疗提供一些参考依据。方法 (1)选取2010年9月～2012年11月急性脑出血患者102例,并选取20例健康体检者,作为健康对照组。(2)标本采集、处理和储存。(3)脑血肿量及血肿周围的水肿量测定。(4)炎症因子的检测。(5)对所有相关数据进行统计分析。结果 (1)基底节区急性脑出血病患的血清之中的白细胞介素-4、白细胞介素-6、白细胞介素-8、白细胞介素-10浓度水平均明显高于健康对照组(P0.05)；而血肿液以及静脉血中的白细胞介素-4、白细胞介素-6、白细胞介素-8、白细胞介素-10浓度水平则无明显差异(P0.05)。 (2)基底节区急性脑出血病患6h内的血清之中的白细胞介素-4、白细胞介索-6、白细胞介素-8浓度水平均明显高于健康对照组(P0.05)：而白细胞介素-10则与健康对照组无明显差异(P0.05)。24-72h时白细胞介素-4、白细胞介素-6、白细胞介素-8则均达峰值,至3-7d时呈下降趋势,均明显高于健康对照组(P0.05)。 (3)基底节区急性脑出血病患在6h-7d之内水肿量以及出血量之间呈正相关,具统计学意义(P0.05)。 (4)白细胞介素-4、白细胞介素-6、白细胞介素-8、白细胞介素-10两两之间均具相关性,且.均呈正相关。 (5)白细胞介素-4、白细胞介素-6、白细胞介素-8、白细胞介素-10各炎症因子对急性脑出血病患的脑水肿的影响以及作用强度呈现为白细胞介素-4白细胞介素-10白细胞介素-6白细胞介素-8。结论 (1)急性脑出血患者体内白细胞介素-4、白细胞介素-6、白细胞介素-8、白细胞介素-10浓度明显高于健康对照组。 (2)急性脑出血患者6h-7d内水肿量与出血量呈正相关。 (3)各炎症因子对急性脑出血后脑水肿的影响强度依次为II-4IL-10IL-6 IL-8。 (4)急性脑出血病患体内IL-4、IL-10对血肿周围水肿量的作用较大,应加强对抗炎因子的重视,并可以根据病患实际情况来制定不同的治疗方案。
[Abstract]:Background It was found that IL - 1 , IL - 2 , IL - 4 , IL - 6 , IL - 8 , IL - 10 , IL - 18 and TNF - 伪 play an important role in the formation of brain edema after intracerebral hemorrhage . Purpose To determine the level of interleukin - 4 , interleukin - 6 , interleukin - 8 and interleukin - 10 in brain hematoma fluid and serum of patients with cerebral hemorrhage , to explore the mechanism of brain edema , the relationship between inflammatory factors and brain edema and their correlation with each other , and to provide some reference for future clinical treatment . method ( 1 ) 102 patients with acute cerebral hemorrhage from September 2010 to November 2012 were selected and 20 healthy controls were selected as healthy controls . ( 2 ) The samples were collected , treated and stored . ( 3 ) The amount of brain hematoma and edema around hematoma were measured . Results ( 1 ) The levels of IL - 4 , IL - 6 , IL - 8 and IL - 10 in serum of patients with acute cerebral hemorrhage in basal ganglia were significantly higher than those in healthy control group ( P0.05 ) , but there was no significant difference in the levels of IL - 4 , IL - 6 , IL - 8 and IL - 10 in hematoma fluid and venous blood ( P0.05 ) . ( 2 ) The levels of IL - 4 , IL - 6 and IL - 8 in serum of patients with acute cerebral hemorrhage in basal ganglia were significantly higher than those in healthy control group ( P0.05 ) . ( 3 ) There was positive correlation between the amount of edema and the amount of bleeding within 6 - 7 days of acute cerebral hemorrhage in basal ganglia region ( P0.05 ) . ( 4 ) The correlation between IL - 4 , IL - 6 , IL - 8 and IL - 10 was positively correlated . ( 5 ) The effects of IL - 4 , IL - 6 , IL - 8 , IL - 10 inflammatory factors on brain edema in patients with acute cerebral hemorrhage were presented as interleukin - 4 interleukin - 6 interleukin - 6 . Conclusion ( 1 ) The levels of IL - 4 , IL - 6 , IL - 8 and IL - 10 in patients with acute cerebral hemorrhage were significantly higher than those in healthy controls . ( 2 ) The amount of edema in 6 - 7 days of acute cerebral hemorrhage was positively correlated with the amount of hemorrhagic volume . ( 3 ) The effect of each inflammatory factor on brain edema after acute cerebral hemorrhage was II - 4IL - 10IL - 6 IL - 8 . ( 4 ) In patients with acute cerebral hemorrhage , IL - 4 and IL - 10 play a role in the amount of edema around hematoma , the importance of anti - inflammatory factors should be strengthened , and different treatment schemes can be developed according to the actual conditions of patients .

【学位授予单位】：新乡医学院
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R743.34

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