氨溴索辅助支气管肺泡灌洗术对颅脑外伤患者行气管切开后相关指标的影响

发布时间：2018-02-23 22:18

本文关键词： 氨溴索支气管肺泡灌洗术颅脑外伤气管切开肺部感染　出处：《中国药房》2016年33期 　论文类型：期刊论文

【摘要】：目的:探讨氨溴索辅助支气管肺泡灌洗(BAL)术对颅脑外伤患者行气管切开后相关指标的影响。方法:90例颅脑外伤行气管切开患者随机分为对照组(45例)和观察组(45例)。两组患者均行止血、吸痰、气管雾化、持续吸氧及抗菌药物预防应用等常规治疗。在此基础上,对照组患者行BAL术;观察组患者于BAL术后加用盐酸氨溴索注射液30 mg,加入0.9%氯化钠注射液100 ml中,静脉滴注,每日3次。两组疗程均为7 d。观察两组患者术后肺部感染发生情况,术后1、3、5、7 d的白细胞计数和多形核细胞计数。结果:观察组患者铜绿假单胞菌、鲍曼不动杆菌、肺炎克雷伯菌和金黄色葡萄球菌感染发生率均显著低于对照组,差异均有统计学意义(P0.05)。术后,两组患者白细胞计数、多形核细胞计数均显著低于同组术前,随时间延长逐渐降低,且观察组低于对照组,差异均有统计学意义(P0.05)。结论:在常规治疗的基础上,氨溴索辅助BAL术可有效降低颅脑外伤患者行气管切开后的肺部感染发生率及炎症水平。
[Abstract]:Objective: to investigate the effect of ambroxol assisted bronchoalveolar lavage (BALs) on the related indexes after tracheotomy in patients with craniocerebral trauma. Methods: 90 patients with craniocerebral trauma underwent tracheotomy were randomly divided into control group (n = 45) and observation group (n = 45). Two groups of patients were treated with hemostasis, Sputum inhalation, trachea atomization, continuous inhalation of oxygen and prophylactic application of antimicrobial agents, etc. On this basis, the patients in the control group were treated with BAL, the patients in the observation group were treated with ambroxol hydrochloride injection 30 mg after BAL, and 0.9% ml sodium chloride injection was added to the treatment group. The incidence of pulmonary infection, leukocyte count and polymorphonuclear cell count were observed in two groups after operation. Results: Pseudomonas aeruginosa, Acinetobacter baumannii, Pseudomonas aeruginosa, Acinetobacter baumannii were observed in the observation group. The incidence of Klebsiella pneumoniae and Staphylococcus aureus infection was significantly lower than that of the control group (P 0.05). As the time went on, it gradually decreased, and the observation group was lower than the control group, the difference was statistically significant (P 0.05). Conclusion: on the basis of routine treatment, Ambroxol combined with BAL can effectively reduce the incidence of pulmonary infection and inflammation after tracheotomy in patients with craniocerebral trauma.
【作者单位】：衡水市哈励逊国际和平医院重症医学科;
【分类号】：R651.1+1

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