阿替普酶与尿激酶治疗急性脑梗死疗效的比较研究

发布时间：2018-02-26 17:04

本文关键词： 阿替普酶尿激酶溶栓疗效　出处：《中风与神经疾病杂志》2016年07期 　论文类型：期刊论文

【摘要】：目的对比阿替普酶和尿激酶治疗急性脑梗死的疗效。方法收集哈尔滨医科大学附属第一医院神经内科静脉溶栓治疗的急性脑梗死患者158例,根据所用溶栓药物分为两组:rt-Pa组患者53例。UK组患者105例,其中发病4.5 h内患者80例,构成4.5 UK组。神经功能缺失评定采用NIHSS评分。分别观察溶栓后2 h、24h、7 d、10 d疗效。结果(1)rt-Pa组在2 h、24 h疗效优于UK组(P0.05),rt-Pa组和UK组在7 d和10 d疗效无明显差异(P0.05)。(2)rt-Pa组在2 h、24 h疗效优于4.5 UK组(P0.05),rt-Pa组和4.5UK组在7 d和10 d疗效无明显差异(P0.05)。结论阿替普酶在溶栓后24 h内疗效优于尿激酶,但二者的短期预后相当。
[Abstract]:Objective to compare the efficacy of atropase and urokinase in the treatment of acute cerebral infarction. Methods 158 patients with acute cerebral infarction treated with intravenous thrombolytic therapy in Department of Neurology, first affiliated Hospital of Harbin Medical University, were collected. According to the thrombolytic drugs used, the patients were divided into two groups: 53 patients in the group of 10: rt-Pa. 105 patients in the UK group, among which 80 patients were within 4.5 hours of onset of the disease. NIHSS score was used to evaluate neurologic function loss. The curative effect was observed at 24 hours and 7 days after thrombolysis. Results the curative effect of rt-Pa group was better than that of UK group P0.05 + rt-Pa group and UK group at 7 and 10 days after thrombolysis. Results there was no significant difference between UK group and UK group on 7 and 10 days after thrombolytic thrombolytic therapy (P0.05.2rt-Pa). There was no significant difference in the curative effect between the 4.5UK group and 4.5UK group at 7 and 10 days. Conclusion Atiprase is superior to urokinase within 24 hours after thrombolytic therapy, and there is no significant difference in the therapeutic effect between 4.5UK group and 4.5UK group in 7 days and 10 days after thrombolytic therapy. But their short-term prognosis is similar.
【作者单位】：山东医学高等专科学校内科教研室;哈尔滨医科大学第一附属医院神经内科;
【分类号】：R743.3

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