H-FABP在急性心梗早期判断冠脉病变程度的研究

发布时间：2018-02-27 14:20

  本文关键词： 心型脂肪酸结合蛋白 急性心肌梗死 冠脉狭窄程度　出处：《新疆医科大学》2014年硕士论文　论文类型：学位论文

【摘要】：目的：探讨血清心型脂肪酸结合蛋白(H-FABP)的浓度在急性心肌梗死患者早期评估冠脉病变程度的意义及应用价值。方法：选取2012年12月至2013年12月就诊于新疆医科大学第一附属医院急诊科的急性心肌梗死患者122例作为病例组,同时选取相同时间段就诊该院体检科患者50人作为对照组。检测其血清CK、CK-MB、TnT的浓度,同时运用ReLIA多功能免疫检测仪器检测其心型脂肪酸结合蛋白血清浓度。分析上述指标与冠脉病变程度的关系。冠依据状动脉造影结果分类：单支病变组病变累及1支患者47例。病变累及2支患者44例。病变累及2支以上患者31例。冠状动脉病变狭窄直径在50%～70%之间的为轻度狭窄37例。冠状动脉病变狭窄直径在71%-89%之间的为中都狭窄36例。冠状动脉病变狭窄直径为≥90%为重度狭窄49例。比较各组与对照组间及各组之间上述心肌酶标记物及H-FABP浓度是否存在差异。计量资料采用均数±标准差(标准误),并完成正态性及方差齐性检验,方差齐采用独立样本t检验行组间比较,方差不齐采用独立样本t’检验行组间比较,计数资料用卡方检验,检验标准a=0.05,P0.05为有统计学意义。结果：(1)单支病变组、双支病变组及多支病变组CK、CK-MB、TnT、H-FABP浓度显著高于对照组,差异有统计学意义(P0.05)。(2)双支病变组、多支病变组检测H-FABP浓度均显著高于单支病变组,差异有统计学意义(P0.05)。(3)轻度狭窄组、中度狭窄组及重度狭窄组CK、CK-MB、TnT、H-FABP浓度显著高于对照组,差异有统计学意义(P0.05)。(4)中度狭窄组、重度狭窄组检测H-FABP浓度均显著高于轻度狭窄组,差异有统计学意义(P0.05)。结论：急性心肌梗死早期血清H-FABP浓度越高提示冠脉病变程度越重。
[Abstract]:Objective: to investigate the clinical significance and value of serum cardiac fatty acid binding protein H-FABPin in the early assessment of coronary artery disease in patients with acute myocardial infarction. Methods: from December 2012 to December 2013, we selected to visit Xinjiang Medical University from December 2012 to December 2013. 122 patients with acute myocardial infarction in the emergency department of the first affiliated Hospital were selected as the case group. At the same time, 50 patients in the same period of time were selected as the control group. The serum levels of CKCK-MBN TnT were measured. At the same time, the serum concentration of cardiac fatty acid binding protein was detected by ReLIA multifunctional immunoassay. The relationship between the above indexes and the severity of coronary artery lesion was analyzed. The coronal classification was based on the results of coronary arteriography. There were 47 patients with one vessel, 44 patients with 2 branches, 31 patients with more than 2 vessels. 37 patients with coronary artery stenosis between 50% and 70% had slight stenosis. The diameter of coronary artery stenosis ranged from 71% to 89%. There were 36 cases of moderate stenosis and 49 cases of severe stenosis with stenosis diameter 鈮，

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