血清CXCL12和IL-33在急性缺血性脑卒中预后评估中的价值

发布时间：2018-03-05 04:03

  本文选题：CXCL　切入点：IL-　出处：《中国免疫学杂志》2017年10期 　论文类型：期刊论文

【摘要】：目的:探讨血清CXCL12和IL-33在急性缺血性脑卒中预后评估中的价值。方法:选取2014年12月至2016年6月到本院就诊的急性缺血性脑卒中患者作为病例组(122例),同时选取本院同期健康体检人群作为正常组(59名),采用ELISA法检测研究对象入组时血清CXCL12和IL-33的水平。参照mRS评分将患者分为预后良好组(86例)和预后不良组(36例),并通过受试者工作特征曲线(ROC)和曲线下面积(AUC)评价血清CXCL12和IL-33在急性缺血性脑卒中患者预后评估中的作用。结果:急性缺血性脑卒中患者血清CXCL12水平明显高于对照组[8.0 ng/ml(IQR,6.7-8.9)VS 3.0 ng/ml(IQR,2.3-3.8),P0.001],IL-33水平明显高于对照组[65.25 ng/L(IQR,56.05-71.08)VS 35.30 ng/L(IQR,26.73-42.55),P0.001];急性缺血性脑卒中预后良好组患者血清CXCL12水平明显低于预后不良组[7.4 ng/ml(IQR,6.3-8.3)VS 9.3 ng/m L(IQR,8.3-11.1),P0.001],预后良好组患者IL-33水平明显高于预后不良组[66.81 ng/L(IQR,61.12-73.29)VS.55.38ng/L(IQR,46.75-64.71),P0.001]。经Pearson相关性分析显示血清CXCL12和IL-33水平与mRS评分分别呈正相关和负相关(r=0.524,P0.001;r=-0.443,P0.001)。血清CXCL12、IL-33评估急性缺血性脑卒中预后的曲线下面积分别为0.835、0.784,灵敏度分别为77.8%、83.4%,特异度分别为73.3%、66.7%。结论:血清CXCL12和IL-33可能作为急性缺血性脑卒中患者预后评估的标志物。
[Abstract]:Objective: to evaluate the prognostic value of serum CXCL12 and IL-33 in patients with acute ischemic stroke. Methods: 122 patients with acute ischemic stroke from December 2014 to June 2016 were selected. The serum levels of CXCL12 and IL-33 were measured by ELISA method in 59 normal controls. According to mRS score, the patients were divided into good prognosis group (86 cases) and poor prognosis group (36 cases). The role of serum CXCL12 and IL-33 in evaluating the prognosis of patients with acute ischemic stroke was evaluated. Results: the level of serum CXCL12 in patients with acute ischemic stroke was significantly higher than that in the control group [8.0]. The levels of IL-33 in IQR 6.7-8.9 vs 3.0 ng / ml IQR 2.3-3.8P0.001 were significantly higher than those in the control group [56.05-71.08VS 35.73-42.55P0.001]; the serum CXCL12 level in patients with good prognosis of acute ischemic stroke was significantly lower than that in patients with poor prognosis [7.4ngml / ml IQR6.3-8.3VS 9.3 ng/m IQR (8.3-11.1ng / P0.001)], and the IL-33 level in good prognosis group was significantly higher than that in poor prognosis group (66.81% vs 8.3-8.3VS 9.3 ng/m P0.001). Pearson correlation analysis showed that the serum CXCL12 and IL-33 levels were positively and negatively correlated with the mRS score, respectively. The area under the curve of serum CXCL12IL-33 for evaluating the prognosis of acute ischemic stroke was 0.835 卤0.784, and the sensitivity was 77.80.34, respectively. Conclusion: serum CXCL12 and IL-33 may be used as prognostic markers in patients with acute ischemic stroke.
【作者单位】： 南开大学附属医院(天津市第四医院)神经内科;
【分类号】：R743.3
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本文编号：1568637