急性缺血性脑卒中患者重度脑白质病变的危险因素分析

发布时间：2018-03-07 00:00

本文选题：缺血性脑卒中　切入点：脑白质病变　出处：《重庆医学》2016年11期 　论文类型：期刊论文

【摘要】：目的探讨急性缺血性脑卒中患者重度脑白质病变(WML)发生情况及其危险因素。方法入选248例急性缺血性脑卒中患者,调查患者的一般资料,Fazekas量表对WML严重程度评定并根据评定结果分为重度组和非重度组,对比观察两组患者一般资料差异,以重度WML为应变量,将单因素筛选的可能影响因素作为自变量进行多因素Logistic回归分析。结果248例急性缺血性脑卒中患者中发生重度WML 106例,发生率为42.74%;单因素分析发现,重度组年龄显著高于非重度组,合并高血压、糖尿病发生率显著高于非重度组,差异均有统计学意义(P0.05);多因素Logistic回归分析发现,年龄(OR=4.116,95%CI:1.816~6.454,P=0.000)、高血压(OR=1.462,95%CI:0.842~1.946,P=0.026)和糖尿病(OR=1.157,95%CI:0.698~1.673,P=0.038)是急性缺血性脑卒中患者发生重度WML的独立危险因素。结论急性缺血性脑卒中患者重度WML发生率较高,临床要对高龄及合并高血压、糖尿病等高危人群采取针对性预防措施,以降低重度WML发生。
[Abstract]:Objective to investigate the incidence and risk factors of severe leukoencephalopathy in patients with acute ischemic stroke. Methods 248 patients with acute ischemic stroke were selected. The general data of the patients were investigated and the severity of WML was assessed by Fazekas scale. According to the evaluation results, the patients were divided into two groups: severe group and non-severe group. The difference of general data between the two groups was compared and observed, with severe WML as the dependent variable. Multivariate Logistic regression analysis was carried out using univariate screening as independent variable. Results severe WML occurred in 106 of 248 patients with acute ischemic stroke, and the incidence rate was 42.74.The univariate analysis showed that, The age of severe group was significantly higher than that of non-severe group, the incidence of diabetes mellitus was significantly higher than that of non-severe group, and the incidence of diabetes was significantly higher than that of non-severe group (P 0.05). The risk factors of severe WML in patients with acute ischemic stroke are the age of 4.116-95 CI: 1.816 / 6.454p 0.000, hypertension 1.46295 CI: 0.8421.946P0.026) and diabetes mellitus 1.15795CI0.6981.673P0.038. conclusion the incidence of severe WML in patients with acute ischemic stroke is higher than that in patients with acute ischemic stroke, and the incidence of severe WML in patients with acute ischemic stroke is higher than that in patients with acute ischemic stroke, and the incidence of severe WML in patients with acute ischemic stroke is higher than that in patients with acute ischemic stroke, and the incidence of severe WML in patients with acute ischemic stroke is higher than that in patients with acute ischemic stroke, and the incidence of severe WML is higher in patients with acute ischemic stroke. High-risk groups such as diabetes mellitus take preventive measures to reduce the incidence of severe WML.
【作者单位】：南通大学附属医院神经内科;
【分类号】：R743.3

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