纳洛酮、醒脑静联合治疗老年急性安眠药中毒的疗效及对生活功能的影响

发布时间：2018-03-10 01:00

本文选题：急性安眠药中毒　切入点：纳洛酮　出处：《中国老年学杂志》2017年12期 　论文类型：期刊论文

【摘要】：目的探讨纳洛酮、醒脑静联合治疗老年急性安眠药中毒的疗效及对生活功能的影响。方法 99例急性安眠药中毒患者,其中观察组47例给予纳洛酮+醒脑静联合治疗,对照组52例单独使用纳洛酮静脉滴注。结果观察组血清中肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6及IL-8水平显著低于对照组(P0.05);观察组轻度、中度、重度患者苏醒时间均显著短于对照组(P0.05);两组治疗后均未出现不良药物反应。观察组重度中毒治疗后日常生活能力评分(ADL)明显高于对照组(P0.039)。结论纳洛酮、醒脑静联合治疗可缩短急性安眠药中毒患者苏醒时间,抑制TNF-α、IL-6及IL-8的合成,可明显改善重度中毒患者自理生活能力,无不良药物反应,治疗效果优于单纯使用纳洛酮的患者。
[Abstract]:Objective to investigate the effect of naloxone and Xingnaojing in the treatment of senile acute hypnotic poisoning and its effect on life function. Methods Ninety-nine patients with acute hypnotic poisoning were treated with naloxone xingnaojing in the observation group. Results the serum levels of TNF- 伪, IL-6 and IL-8 in the control group were significantly lower than those in the control group (P 0.05). The recovery time of severe patients was significantly shorter than that of control group (P 0.05), and no adverse drug reaction occurred in both groups. The ADL score of observation group after severe poisoning was significantly higher than that of control group (P 0.039). Xingnaojing combined therapy can shorten the recovery time of patients with acute hypnotic poisoning, inhibit the synthesis of TNF- 伪 -IL-6 and IL-8, and improve the self-care ability of patients with severe poisoning. There is no adverse drug reaction, and the therapeutic effect is better than that of patients using naloxone alone.
【作者单位】：天津医科大学总医院保健医疗部;
【分类号】：R595.4

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