老年急性脑梗死患者血清Hepc25、PF、TRF水平动态变化及其在早期病情和预后评估中的应用

发布时间：2018-03-11 04:00

本文选题：脑梗死　切入点：急性脑梗死　出处：《山东医药》2016年27期 　论文类型：期刊论文

【摘要】：目的分析血清铁调素25(Hepc25)、铁蛋白(PF)和转铁蛋白(TRF)对老年急性脑梗死患者早期病情及其预后的评估价值。方法 227例老年急性脑梗死患者(观察组,其中轻型73例、中型79例和重型75例)分别于发病24、48、72 h及7、14、28 d时检测血清Hepc25、PF和TRF。80例老年健康体检者(对照组)检测血清Hepc25、PF和TRF。比较发病24、48、72 h及7、14、28 d时观察组和对照组血清Hepc25、PF和TRF。发病28 d时判定观察组预后。分析老年急性脑梗死患者血清Hepc25、PF、TRF与神经功能缺损程度及预后的关系。结果发病24、48、72 h及7、14、28 d时观察组血清Hec25和PF水平均高于对照组,TRF水平均低于对照组(P均0.05);发病24、48、72 h及7、14、28 d时,随NIHSS评分升高,观察组血清Hepc25、PF升高,TRF水平降低(P均0.05)。观察组分为基本痊愈42例、显著进步84例、进步67例和无变化34例。发病24、48、72 h及7、14、28 d时,观察组基本痊愈、显著进步和进步者血清Hepc25、PF均低于,TRF水平高于无变化者(P均0.05);发病24 h时血清Hepc25、PF均与NIHSS呈正相关(r=0.704和0.653,P均0.05),TRF与NIHSS呈负相关(r=-0.614,P0.05);发病28 d时血清Hepc25、PF均与患者预后呈负相关(r=-0.692和-0.517,P均0.05),TRF与患者预后呈正相关(r=0.635,P0.05)。结论老年急性脑梗死患者存在血清Hepc25、PF、TRF动态变化。血清Hepc25、PF、TRF动态变化可用于老年急性脑梗死患者早期病情预后评估。
[Abstract]:Objective to analyze the value of serum ferritin 25 Hepc25 (PFF) and transferrin (TRFs) in evaluating the early state of illness and prognosis of elderly patients with acute cerebral infarction. Methods 227 elderly patients with acute cerebral infarction (observation group, 73 patients with mild cerebral infarction) were included in the study group. The serum Hepc25PF and TRFs were detected in 79 cases of moderate and 75 cases of severe disease at 24 hours and 28 days after onset, respectively. The serum Hepc25PF and TRFs of the observation group and the control group were compared at 24: 872 hours and 714 days after the onset of the disease, and the serum Hepc25PF and TRFs of the control group were compared with those of the control group at 24: 4872 hours and 714 days after the onset of the disease, and the serum Hepc25PF and TRFs of the control group were compared with those of the control group. The prognosis of the observation group was evaluated at 28 days after onset, and the relationship between the serum Hepc25 PFFRF and the degree of neurological function defect and prognosis was analyzed. Results the serum Hec25 and PF levels in the observation group were higher than those in the control group at 24: 48 hours and 714 days after onset. The levels were lower than those in the control group (P < 0.05), and at the onset of the disease (24 ~ 48 ~ 72h) and at ~ (714) ~ (28) d, respectively. With the increase of NIHSS score, the serum levels of Hepc25PF increased and the levels of TRF decreased (P < 0.05). In the observation group, 42 cases were basically cured, 84 cases improved significantly, 67 cases improved and 34 cases showed no change. The serum levels of Hepc25PF were significantly lower than those of TRF in patients with significant progress and progression than those without change (P = 0.05), and were positively correlated with NIHSS at 24 h after onset. There was a negative correlation between serum Hepc25PF and NIHSS, and a negative correlation between serum Hepc25PF and NIHSS, and a negative correlation between serum Hepc25PF and the prognosis of the patients at 28 days after onset. There was a positive correlation between TRF and prognosis in patients with acute cerebral infarction. Conclusion there are dynamic changes of serum Hepc25 PFTRF in elderly patients with acute cerebral infarction, and the dynamic changes of serum Hepc25 + PFN TRF can be used to evaluate the early prognosis of elderly patients with acute cerebral infarction.
【作者单位】：山东大学附属第二医院;山东省妇幼保健院;
【基金】：河南省科技计划项目(142102310417)
【分类号】：R743.3

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