全身炎症反应和心律失常风险相关性研究进展

发布时间：2018-03-12 08:04

本文选题：类风湿性关节炎　切入点：全身炎症反应　出处：《临床心血管病杂志》2017年08期 　论文类型：期刊论文

【摘要】：类风湿性关节炎中超过50%的患者死于心血管疾病,其心源性猝死的发生率是非类风湿性关节炎患者的2倍,且更易发生恶性室性心律失常。类风湿性关节炎致心律失常的机制可能是全身慢性炎症反应激活后,通过加速缺血性心脏病和充血性心力衰竭的发生发展,影响心脏电生理,从而促使心律失常的发生。因此,通过严格控制类风湿性关节炎疾病活动性以降低炎症负担,可能是减少类风湿性关节炎患者心律失常发生风险最有效的干预措施。
[Abstract]:More than 50% of rheumatoid arthritis patients died of cardiovascular disease, and the incidence of sudden cardiac death was twice that of non-rheumatoid arthritis patients. The mechanism of arrhythmia caused by rheumatoid arthritis may be that after the activation of systemic chronic inflammatory reaction, it may affect cardiac electrophysiology by accelerating the occurrence and development of ischemic heart disease and congestive heart failure. Therefore, to reduce the burden of inflammation by strictly controlling the activity of rheumatoid arthritis may be the most effective intervention to reduce the risk of arrhythmia in patients with rheumatoid arthritis.
【作者单位】：南昌大学第二附属医院心内科;江西省分子医学重点实验室;
【基金】：国家自然科学基金重点项目(No:81530013)
【分类号】：R541.7

【相似文献】