舒血宁注射液联合神经节苷脂对急性重度CO中毒患者的保护作用

发布时间：2018-03-14 10:03

本文选题：舒血宁注射液　切入点：神经节苷脂　出处：《中成药》2017年07期 　论文类型：期刊论文

【摘要】：目的考察舒血宁注射液(银杏叶提取物)联合神经节苷脂对急性重度一氧化碳中毒患者脑氧利用率和乳酸清除率的影响。方法 2011年3月至2016年3月入住河北医科大学附属哈励逊国际和平急救医学部的262例急性重度一氧化碳中毒患者随机分为对照组、舒血宁注射液组、神经节苷脂组和舒血宁注射液联合神经节苷脂治疗组(联合用药组)。所有患者检测颈动脉血和静脉血的氧饱和度,动脉血乳酸,治疗前及治疗后6 h、24 h、3 d脑氧利用率和乳酸清除率;观察2周后的临床症状、急性一氧化碳中毒后迟发性脑病的发生率及病死率。结果舒血宁注射液联合神经节苷脂治疗组总有效率高于其他组,联合用药组治疗后6、24 h脑氧利用率明显低于其他组,但乳酸清除率明显高于其他组;联合用药组患者迟发性脑病的发生率和病死率明显低于其他组。所有差异均有统计学意义。结论舒血宁和神经节苷脂联合用药治疗急性重度一氧化碳中毒患者的疗效好于分别用药。
[Abstract]:Objective to investigate the effects of Shuxuening injection (Ginkgo biloba extract) combined with ganglioside on cerebral oxygen utilization rate and lactate clearance rate in patients with acute severe carbon monoxide poisoning. 262 patients with acute severe carbon monoxide poisoning in the Harrison International Department of first Aid Medicine, affiliated to the University of Science, were randomly divided into control groups. Shuxuening injection group, ganglioside group and Shuxuening injection combined with ganglioside treatment group. The cerebral oxygen utilization rate and lactate clearance rate were observed before and 6 hours after treatment, and the clinical symptoms were observed 2 weeks later. Results the total effective rate of Shuxuening injection combined with ganglioside was higher than that of other groups. But the clearance rate of lactic acid was significantly higher than that of other groups. The incidence and mortality of delayed encephalopathy in combined treatment group were significantly lower than those in other groups. Conclusion there is statistical significance in the treatment of acute severe carbon monoxide poisoning with Shuxuening and ganglioside. The curative effect is better than that of separate medication.
【作者单位】：河北医科大学附属哈励逊国际和平医院急救医学部;
【基金】：河北省衡水市科学技术研究与发展计划项目(13019A)
【分类号】：R595.1

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