臭氧治疗对急性脑梗塞内皮素影响的研究

发布时间：2018-03-15 09:24

本文选题：臭氧　切入点：急性期脑梗塞　出处：《辽宁中医药大学》2013年硕士论文　论文类型：学位论文

【摘要】：目的：验证臭氧对急性期脑梗塞治疗作用，并验证内皮素是与临床疗效一致的化验指标，且其数值可反映急性期脑梗塞的患者病情的轻重，并对其作以分析探讨。方法：将于我院救治的急性脑梗塞的患者120例随机分成两组，非臭氧治疗对照组30例，臭氧等综合治疗组90例，对照组行西医吸氧、脱水、抗血小板等常规治疗，治疗组于如上西医常规治疗的基础上，行臭氧治疗，两组疗程均为14天，并监测患者血浆ET水平（住院第1，7,14天），以及进行相关疗效评判，并对记录之结果行统计学分析。结果： 1临床表现治疗组与对照组比，神经功能缺损评分明显降低，，证实治疗组神经功能恢复良好，优于对照组。另外，患者经治疗后，半身不遂或单臂单腿不遂或口眼歪斜或舌强言蹇或不语，头晕目眩、偏身麻木、局部刺痛，等症状较前缓解，治疗组更为明显。 2理化检查治疗组在常规治疗基础上加用臭氧可以使患者急性期内(治疗后7d)ET明显下降，且具有统计学意义。两组组内ET的动态演变和本组内各期的神经功能缺损，评分量表积分变化呈高度正相关，提示检测ET，观察其动态演变在一定程度上可反应患者神经功能改善和神经保护作用。另外，脑梗塞轻度患者ET高于正常组，中重度患者两指标显著高于轻度患者，且呈正相关。提示ET不仅参于脑梗塞病理过程，而且与病情程度呈正相关。且临床治疗有效率高于对照组，提示ET反映了不同程度脑梗塞患者的治疗效果。 3整体疗效治疗后，按照疗效判定标准，行疗效评判，其中，对照组基本治愈1例，显著进步5例，进步13例，无效11例，总有效率63.33%，治疗组基本治愈5例，显著进步39例，进步29例，无效17例，总有效率81.11%，经统计分析证实，治疗组西医临床疗效较对照组更佳，治疗组的总有效率高达81.11%。结论：采用臭氧治疗对急性期脑梗塞的临床疗效满意，内皮素是与脑梗塞的临床疗效一致的化验指标，且其数值标志着患者病情轻重。
[Abstract]:Objective: to verify the therapeutic effect of ozone on acute cerebral infarction, and to verify that endothelin is an index consistent with clinical efficacy, and its value can reflect the severity of patients with acute cerebral infarction. Methods: 120 patients with acute cerebral infarction who were treated in our hospital were randomly divided into two groups: the control group (n = 30), the control group (n = 90), and the control group (n = 90) received routine western medicine therapy, such as oxygen inhalation, dehydration, anti-platelet therapy, etc. The treatment group was treated with ozone on the basis of routine western medicine treatment. The two groups were treated with ozone for 14 days, and the plasma et level was monitored (1 ~ 7 ~ 14 days after hospitalization), and the related curative effect was evaluated, and the recorded results were analyzed statistically. Results:. 1 Clinical manifestations. Compared with the control group, the neurological deficit score of the treatment group was significantly decreased, which proved that the nerve function of the treatment group recovered well and was superior to that of the control group. The symptoms of hemiplegia or one-arm one-leg failure or mouth and eye askew or tongue strong speech or muzzle, dizziness, partial numbness, local stinging pain, and so on were relieved, and the treatment group was more obvious. 2 physical and chemical examination. In the treatment group, the level of et decreased significantly in the acute phase (7 days after treatment) and had statistical significance. The dynamic evolution of et in the two groups and the nerve function defect in each stage of the treatment group were observed. There was a highly positive correlation between the scores and the scores, which suggested that the detection of ETs and the dynamic evolution of ETs could reflect the improvement of neurologic function and the neuroprotective effect of the patients to a certain extent. In addition, et in mild patients with cerebral infarction was higher than that in normal patients, and the two indexes in moderate and severe patients were significantly higher than those in mild patients, which indicated that et was not only involved in the pathological process of cerebral infarction, but also in the pathological process of cerebral infarction. The effective rate of clinical treatment was higher than that of the control group, suggesting that et reflected the therapeutic effect of patients with different degrees of cerebral infarction. 3 overall curative effect. After treatment, according to the criterion of curative effect, the curative effect was evaluated. In the control group, 1 case was basically cured, 5 cases were significantly improved, 13 cases were improved, 11 cases were ineffective, and the total effective rate was 63.33%. In the treatment group, 5 cases were basically cured, 39 cases were improved significantly, 29 cases were improved. 17 cases were ineffective and the total effective rate was 81.11%. The clinical efficacy of western medicine in the treatment group was better than that in the control group, and the total effective rate in the treatment group was as high as 81.11%. Conclusion:. Ozone therapy was used to treat acute cerebral infarction with satisfactory clinical effect. Endothelin is the same test index as the clinical efficacy of cerebral infarction and its value indicates the severity of the patient's condition.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R743.33

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