电针刺激对重型颅脑损伤迁延性昏迷患者昏迷程度的影响及机制

发布时间：2018-03-16 14:51

本文选题：重型颅脑损伤　切入点：迁延性昏迷　出处：《山东医药》2016年12期 　论文类型：期刊论文

【摘要】：目的观察电针刺激对重型颅脑损伤迁延性昏迷患者昏迷程度的影响,并探讨其作用机制。方法将重型颅脑损伤迁延性昏迷患者57例随机分为电针组28例、对照组29例。两组均给予常规治疗,在此基础上电针组入院后72 h给予电针刺激,1次/d,14天为1个疗程,根据患者自身耐受能力连续接受4~6个疗程治疗。两组分别于入院时,治疗后3、7、14天及随访3个月时进行格拉斯哥昏迷(GCS)评分,分别于入院时及治疗后3、7、14天采用胶体金法检测血浆D-二聚体。观察两组治疗期间不良反应。结果随治疗时间延长,两组GCS评分逐渐升高(P均0.05),电针组治疗14天及随访3个月时GCS评分均高于对照组(P0.05或0.01)。随治疗时间延长,两组血浆D-二聚体水平逐渐降低(P均0.05),电针组治疗7、14天时血浆D-二聚体水平低于对照组(P均0.05)。两组均未见严重不良反应。结论电针刺激可降低重度颅脑损伤迁延性昏迷患者的昏迷程度,降低血浆D-二聚体水平可能是其作用机制之一。
[Abstract]:Objective To observe the effect of Electroacupuncture on severe traumatic patients with persistent coma coma degree of injury, and to explore its mechanism. Methods of severe craniocerebral injury patients with persistent coma 57 cases were randomly divided into electroacupuncture group of 28 cases, 29 cases in the control group. Two groups were given conventional treatment, on the basis of the EA group was given 72 h after admission electroacupuncture, 1 /d, 14 days for 1 courses, according to the patients' tolerance for continuous 4~6 cycles of treatment. The two groups were admitted to hospital, Glasgow coma 3,7,14 days after treatment and follow-up of 3 months (GCS) score, respectively at admission and 3,7,14 days after treatment by colloidal gold methods plasma D- dimer detection two. Observed two groups of adverse reactions during treatment. Results with prolonged treatment, the GCS scores of the two groups increased gradually (P < 0.05), EA group for 14 days and 3 months follow-up GCS score were higher than the control group (P0.05 or 0.01) with the rule. Treatment time, two groups of plasma D- two level of D-dimer decreased gradually (P 0.05), the acupuncture treatment group 7,14 D- two days of plasma level of D-dimer was lower than that of control group (P < 0.05). The two groups had no severe adverse reactions. Conclusion electroacupuncture can reduce the damage degree of coma patients with persistent coma in severe brain two, the decrease of plasma D- dimer level may be one of the mechanisms.

【作者单位】：江阴市中医院;
【基金】：江苏省中医药局科技项目(LB11014)
【分类号】：R651.15

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