急性脑梗死患者血清骨桥蛋白水平的改变及其对预后的影响

发布时间：2018-03-17 03:37

本文选题：缺血性脑卒中　切入点：骨桥蛋白(Osteopontin　出处：《中风与神经疾病杂志》2016年03期 　论文类型：期刊论文

【摘要】：目的探究急性脑梗死患者血清骨桥蛋白水平的变化及其对预后的影响。方法详细收集112例急性脑梗死患者及53例健康对照组的临床资料并通过ELISA法测定患者1 d、7 d、12 d血清骨桥蛋白水平,计算脑梗死患者梗死面积,并进行NIHSS评分、TOAST及OCSP分型,采用Pearson相关分析法分析7 d血清骨桥蛋白水平与各危险因素的相关性,根据mRS评分将脑梗死患者分为预后良好组(2分)及预后不良组(2分),比较两亚组血清骨桥蛋白水平,进行Logistic回归分析,探讨其在急性脑梗死预后中的作用。结果急性脑梗死患者7 d血清骨桥蛋白水平较对照组显著升高[(8.05±5.47)ng/ml vs(5.05±2.37)ng/ml,P0.01]。其水平与入院时梗死面积(r=0.254,P=0.007),NIHSS评分(r=0.233,P=0.013)均呈正相关。在Logistic回归分析中,我们发现骨桥蛋白水平6.565 ng/ml是不良预后的独立危险因素(OR=3.207,95%CI 1.212~8.485,P=0.019)。结论骨桥蛋白参与缺血性脑卒中的病理生理过程,可以作为评价急性脑梗死预后的一个重要的生物学指标。
[Abstract]:Objective to investigate the changes of serum osteopontin level in patients with acute cerebral infarction and its influence on prognosis. Methods the clinical data of 112 patients with acute cerebral infarction and 53 healthy controls were collected and measured by ELISA method. The serum osteopontin level was 12 days after treatment. The infarct size of patients with cerebral infarction was calculated, and the NIHSS scores were evaluated by toast and OCSP classification. The correlation between serum osteopontin level and risk factors was analyzed by Pearson correlation analysis. According to mRS score, patients with cerebral infarction were divided into good prognosis group (2 points) and poor prognosis group (2 points). The serum osteopontin levels were compared between the two subgroups, and Logistic regression analysis was performed. Results the serum osteopontin level in patients with acute cerebral infarction at 7 days was significantly higher than that in the control group [8.05 卤5.47 ng / ml vs(5.05 卤2.37 ng / ml P0.01]. We found that the osteopontin level of 6.565 ng/ml is an independent risk factor for poor prognosis. [WT5 "HZ] [WT5" BZ] [WT5 "BZ] [WT5" BZ] [WT5 "BZ] osteopontin is an independent risk factor for poor prognosis.
【作者单位】：中国医科大学附属盛京医院第一神经内科;中国医科大学附属盛京医院第二泌尿外科;
【基金】：重大疾病动物实验研究及临床应用(No.2012225021)
【分类号】：R743.3

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