S100A12在急性呼吸窘迫综合征患者外周血中的表达及意义

发布时间：2018-03-17 13:44

  本文选题：急性呼吸窘迫综合征　切入点：钙结合蛋白　出处：《中国呼吸与危重监护杂志》2017年05期 　论文类型：期刊论文

【摘要】：目的探讨S100A12蛋白水平在急性呼吸窘迫综合征(ARDS)患者外周血中的表达及临床意义。方法纳入潍坊医学院附属医院、潍坊市人民医院2015年10月至2016年12月收治的ARDS患者,根据患者氧合状态选取轻度组(n=20)、中度组(n=20)和重度组(n=20),共60例纳入研究。随访患者30d预后,情况,分为生存组(n=37)和死亡组(n=23)。选取同期60例健康体检者作为对照组。收集所有研究对象临床基本资料。采集所有研究对象清晨空腹静脉血4ml,采用ELISA方法检测血清中S100A12的表达。结果与对照组比较,ARDS患者血清中S100A12、白细胞介素-1(IL-1)、肿瘤坏死因子-α(TNF-α)水平以及急性生理学和慢性健康状况评分系统Ⅱ(APACHEⅡ)评分显著升高,PaO_2/FiO_2明显降低,差异有统计学意义(均P0.05)。S100A12水平与ARDS严重程度呈正相关,重度组患者血清中S100A12水平高于中度组,中度组高于轻度组,差异有统计学意义(均P0.05)。ARDS患者血清中S100A12水平与IL-1、TNF-α、APACHEⅡ评分呈正相关(P0.05),而与PaO_2/FiO_2呈负相关(P0.05)。对死亡组有关影响因素进行Logistic回归分析显示IL-1、TNF-α、APACHEⅡ评分、S100A12是ARDS患者死亡的独立危险因素,PaO_2/FiO_2则是ARDS患者死亡的独立保护因素。ARDS患者血清中S100A12蛋白水平在预后评估时的ROC曲线下面积表明S100A12蛋白水平对ARDS的转归有一定的预测价值,可作为预后评估的辅助性指标。结论 ARDS患者血清中S100A12水平显著升高,与病情严重程度密切相关,对ARDS早期诊断、治疗及预后有着一定的临床应用价值。
[Abstract]:Objective to investigate the expression of S100A12 protein in peripheral blood of patients with acute respiratory distress syndrome (ARDS) and its clinical significance. According to the oxygenation status of the patients, 60 patients were included in the study, who were selected as mild group, moderate group, and severe group, 60 cases were included in the study. The prognosis of the patients was followed up for 30 days. The patients were divided into survival group (n = 37) and death group (n = 23). 60 healthy persons were selected as control group. Basic clinical data of all subjects were collected. Fasting venous blood was collected from all subjects in the morning. Serum S100A12 was detected by ELISA method. Results compared with the control group, the serum levels of S100A12, IL-1- 1, TNF- 伪 and the acute physiology and chronic health status scoring system 鈪，

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