心型脂肪酸结合蛋白和N-末端脑钠肽前体在脓毒症心肌损伤中的变化及意义

发布时间：2018-03-18 15:32

  本文选题：脓毒症　切入点：心肌损伤　出处：《实用医学杂志》2016年17期 　论文类型：期刊论文

【摘要】：目的:探讨脓毒症心肌损伤患者心型脂肪酸结合蛋白(H-FABP)和N-末端脑钠肽前体(NTpro BNP)的变化及临床意义。方法 :118例脓毒症患者按预后分为存活组68例和死亡组50例;体检者50例为对照组。脓毒症患者入院1 h(发病3 h内)、6 h时,对照组体检时检测心肌酶、H-FABP及NT-pro BNP水平、APACHEⅡ评分及28 d病死率。结果:入院1 h,脓毒症患者H-FABP、NT-pro BNP和APACHEⅡ评分高于对照组(P0.05),6 h时c Tn I、H-FABP、NT-pro BNP和APACHEⅡ评分高于1 h(P0.05);死亡组在1 h和6 h时H-FABP、NT-pro BNP和APACHEⅡ评分高于存活组(P0.05);6 h时死亡组c Tn I高于存活组(P0.05)。患者6 h时H-FABP和NT-pro BNP与c Tn I呈正相关(均P0.05)。6 h时H-FABP对28 d病死率的预测能力优于NT-pro BNP及APACHEⅡ评分(P0.05)。结论:H-FABP和NT-pro BNP对脓毒症患者心肌损伤的早期诊断和预后评估有重要意义。
[Abstract]:Objective: to investigate the changes and clinical significance of cardiac fatty acid binding protein (H-FABP) and N-terminal brain natriuretic peptide precursor (NTpro BNPP) in septic myocardial injury patients. Methods: according to the prognosis, 118 septic patients were divided into survival group (n = 68) and death group (n = 50). 50 cases of physical examination served as control group. Sepsis patients were admitted to hospital for 1 hour (within 3 hours after onset of the disease and 6 hours after onset). Results: at 1 h after admission, the scores of H-FABP and NT-pro BNP in the control group were higher than those in the control group at 1 h after admission, and the scores of BNP and APACHE 鈪，

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