血清H-FABP和cTnT水平联合测定在急性心肌梗死诊断中的作用

发布时间：2018-03-18 20:18

本文选题：急性心肌梗死　切入点：心型脂肪酸结合蛋白　出处：《临床心血管病杂志》2017年07期 　论文类型：期刊论文

【摘要】：目的:研究心肌损伤标志物心型脂肪酸结合蛋白(H-FABP)和心肌肌钙蛋白T(cTnT)联合检测在急性心肌梗死(AMI)临床诊断中的作用和意义。方法:采用ELISA方法对33例AMI患者(AMI组)和31例正常对照者(对照组)血清中的H-FABP和cTnT浓度进行测定,比较两组血清样本中H-FABP与cTnT的浓度,并考察HFABP、cTnT及其组合的诊断灵敏度、特异度以及诊断准确率。结果:与对照组相比,AMI组患者血清H-FABP和cTnT浓度均显著增高(P0.05)。H-FABP、cTnT、H-FAB+cTnT的灵敏度分别为60.61%、75.76%、96.97%,特异度分别为:83.55%、85.77%、93.55%,诊断准确率分别为85.94%、85.94%、95.31%。结论:血清H-FABP和cTnT浓度联合测定可为临床AMI患者的确诊提供准确的实验室依据,有助于减少漏诊及误诊。
[Abstract]:Objective: to study the role and significance of combined detection of cardiac fatty acid binding protein (H-FABP) and cardiac troponin TcTnTin in the diagnosis of acute myocardial infarction (AMI). Methods: 33 patients with acute myocardial infarction (AMI) were treated with ELISA method. H-FABP and cTnT were measured in serum of 31 normal controls. The concentrations of H-FABP and cTnT in serum samples of two groups were compared, and the diagnostic sensitivity of H-FABP / cTnT and its combination were investigated. Results: compared with the control group, the serum H-FABP and cTnT concentrations in the AMI group were significantly higher than those in the control group. The sensitivity of H-FABP, H-FABPnTnTnTnTnTnTnTnTnTnTnTnTnTnFAB cTnT was 96.977.The specificity was 83.555.7793.555.The diagnostic accuracy was 85.94n85.940.Conclusion: the serum H-FABP and cTnT were higher than those in the control group. The combined determination of concentration can provide accurate laboratory basis for the diagnosis of clinical AMI patients. It is helpful to reduce missed diagnosis and misdiagnosis.
【作者单位】：江西中医药大学;清华大学化学系生命有机磷化学及化学生物学教育部重点实验室;南京大学医学院附属鼓楼医院检验科;
【分类号】：R542.22

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