ICU患者假丝酵母菌菌血症的预后危险因素分析

发布时间：2018-03-21 00:24

本文选题：重症监护病房　切入点：假丝酵母菌菌血症　出处：《中华医院感染学杂志》2016年01期 　论文类型：期刊论文

【摘要】：目的分析重症监护病房(ICU)假丝酵母菌菌血症患者的临床和微生物特征,评价其死亡的预后危险因素,以指导临床治疗。方法回顾性分析2005年6月-2013年5月医院ICU 69例假丝酵母菌菌血症患者的临床资料,分析病原菌种类、基础疾病、危险因素、预后情况,使用单因素分析及多因素logistic回归分析假丝酵母菌菌血症死亡的相关危险因素;使用SPSS13.0软件对数据进行统计分析。结果血培养共分离到69株假丝酵母菌属,其中白色假丝酵母菌35株占50.7%,光滑假丝酵母菌12株占17.4%,近平滑假丝酵母菌6株占8.7%,热带假丝酵母菌5株占7.2%,经单因素分析及多因素logistic回归分析发现,并发感染性休克(OR=8.601,95%CI为1.756~42.120)、合并细菌菌血症(OR=32.393,95%CI为3.686~284.657)、低蛋白血症(OR=25.496,95%CI为2.876~226.067)为死亡的独立危险因素。结论 ICU假丝酵母菌菌血症以白色假丝酵母菌为主,病死率高,应针对危险因素采取相应治疗措施。
[Abstract]:Objective to analyze the ICU (ICU) clinical and microbiological characteristics of Candida bacteremia patients, to evaluate the prognostic factors of death, to guide clinical treatment. Methods Retrospective analysis of June 2005 May -2013 hospital ICU 69 cases of Candida bacteremia in patients with clinical data, analysis the types of pathogens, underlying diseases, risk factors the prognosis of logistic was analyzed using univariate and multivariate regression analysis of risk factors of death of yeast Candida bacteremia; statistical analysis of data using SPSS13.0 software. The results of blood cultures were isolated from 69 strains of Candida, the Candida albicans accounted for 50.7% of 35 strains, 12 strains of Candida glabrada accounted for 17.4%. 6 strains of Candida parapsilosis accounted for 8.7%, Candida tropicalis 5 strains accounted for 7.2%, by single factor analysis and multivariate logistic regression analysis showed that septic shock (OR= 8.601,95%CI 1.756~42.120 (OR=32.393,95%CI), bacteremia associated with bacterial 3.686~284.657), hypoproteinemia (OR=25.496,95%CI 2.876~226.067) is an independent risk factor for death. Conclusion ICU Candida bacteremia with Candida albicans, high fatality rate, should take corresponding treatment measures according to the risk factors.

【作者单位】：宁波市医疗中心李惠利医院重症医学科;宁波市第二医院呼吸内科;
【基金】：浙江省自然科学基金资助项目(LY13H190008)
【分类号】：R459.7;R519

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