治疗前血浆和肽素水平在急性脑梗死患者预后评估中的应用效能

发布时间：2018-03-22 09:40

本文选题：和肽素　切入点：急性脑梗死　出处：《山东医药》2017年11期 　论文类型：期刊论文

【摘要】：目的探讨治疗前血浆和肽素水平在急性脑梗死(ACI)患者预后评估中的效能。方法采用ELISA法检测78例急性脑梗死(ACI)患者治疗前血浆和肽素水平。将患者按预后分为预后不良和预后良好组,比较两组患者治疗前(入院时)血浆和肽素水平。绘制治疗前血浆和肽素水平、美国国立卫生研究院卒中量表(NIHSS)评分预测78例ACI患者预后的受试者工作曲线(ROC曲线),计算曲线下面积(AUC)后进行比较。结果 78例患者中预后良好53例、预后不良25例。预后良好组、预后不良组治疗前血浆和肽素水平分别为(32.1±23.3)、(86.8±37.1)pmol/L,预后不良组ACI患者治疗前血浆和肽素水平明显高于预后良好组,P0.05。治疗前血浆和肽素水平、NIHSS评分预测78例ACI患者预后的ROC曲线的AUC分别为0.894、0.967,二者的预测效能相当。结论治疗前血浆和肽素水平在ACI患者预后评估时的效能较好。
[Abstract]:Objective to evaluate the efficacy of plasma and peptide levels in evaluating the prognosis of patients with acute cerebral infarction (ACI) before treatment. Methods the levels of plasma and peptide in 78 patients with acute cerebral infarction (ACI) before treatment were measured by ELISA method. The patients were divided into two groups according to their prognosis. Group with poor posterior and good prognosis, The plasma and peptide levels before treatment were compared between the two groups. The NIHSS score of the National Institutes of Health (NIH) was used to predict the prognosis of 78 patients with ACI by comparing the operating curve with the area under the curve and the area under the curve. Results 53 of the 78 patients had a good prognosis. Poor prognosis 25 cases. Good prognosis group, The levels of plasma and peptide in poor prognosis group before treatment were 86.8 卤37.1pmol / L, respectively. The levels of plasma and peptide in ACI patients with poor prognosis were significantly higher than those in patients with good prognosis (P 0.05). NIHSS scores predicted the prognosis of 78 patients with ACI before treatment. The AUC of the ROC curve was 0.894 ~ 0.967.The predictive efficacy of the two curves was similar. Conclusion Plasma and peptide levels are better in evaluating the prognosis of ACI patients before treatment.
【作者单位】：天津医科大学一中心临床学院;天津中医药大学研究生院;天津市第一中心医院;
【基金】：天津市卫计委科技基金资助项目(2015KZ022)
【分类号】：R743.33

【相似文献】