老年脓毒症患者肠屏障变化与预后的相关性

发布时间：2018-03-25 12:28

  本文选题：脓毒症　切入点：肠屏障　出处：《中国老年学杂志》2017年09期

【摘要】：目的探讨老年脓毒症患者的肠屏障变化情况及其与预后的相关性。方法选择老年脓毒症患者119例,根据脓毒症严重程度分为轻中度脓毒症组68例和重度脓毒症组51例,按照28 d预后分为预后良好组76例和预后不良组43例。检测血浆D-乳酸、二胺氧化酶(DAO)及肠型脂肪酸结合蛋白(IFABP)含量。比较不同组别组急性生理学及慢性健康状况评分系统(APACHE)Ⅱ评分、D-乳酸、DAO及IFABP含量变化。结果重度脓毒症组APACHEⅡ评分高于轻中度脓毒症组(P0.05);重度脓毒症组血浆D-乳酸、DAO及IFABP含量高于轻中度脓毒症组(P0.05);预后不良组APACHEⅡ评分高于预后良好组(P0.05);预后不良组血浆D-乳酸、DAO及IFABP含量高于预后良好组(P0.05)。结论肠屏障功能血浆D-乳酸、DAO及IFABP与老年脓毒症患者病情严重程度及预后判断密切相关。
[Abstract]:Objective to investigate the changes of intestinal barrier in elderly patients with sepsis and its correlation with prognosis. Methods 119 elderly patients with sepsis were divided into mild to moderate sepsis group (n = 68) and severe sepsis group (n = 51) according to the severity of sepsis. According to the prognosis of 28 days, the patients were divided into good prognosis group (76 cases) and poor prognosis group (43 cases). The contents of diamine oxidase (DAO) and intestinal fatty acid binding protein (IFABP) were compared in different groups of patients with acute physiology and chronic health status scoring system (APACHE) 鈪，

本文编号：1663130