尿肝型脂肪酸结合蛋白在颅脑外伤中应用价值

发布时间：2018-04-01 04:16

本文选题：颅脑外伤　切入点：尿肝型脂肪酸结合蛋白　出处：《南方医科大学学报》2016年11期

【摘要】：目的探讨尿肝型脂肪酸结合蛋白(L-FABP)在早期判断颅脑外伤患者病情严重程度及急性肾损伤(AKI)发生的价值,为临床治疗提供依据。方法收集不同严重程度的颅脑外伤患者65例,按GCS评分高低分4组,分别于伤后2、6、12、24、48和72 h留取血和尿标本,生化分析仪检测血清肌酐(SCr)水平,酶联免疫吸附法(ELISA)检测尿L-FABP水平,15例健康成人作为对照。分析血SCr及尿L-FABP水平与患者入院时GCS评分、AKI发生的相关性。结果实验B、C、D组血SCr与尿L-FABP水平较对照组明显升高(P0.05),随着GCS评分的降低(严重程度增高),血SCr与尿L-FABP水平逐渐升高,呈现负相关性(P0.05),尿L-FABP升高较血SCr升高更加明显;AKI发生率约21.54%,AKI患者的尿L-FABP升高高峰期在伤后6 h,SCr升高高峰期在伤后24~48 h,尿L-FABP较SCr升高时间点明显提前。结论尿L-FABP测定可作为早期预判颅脑外伤病情及预测AKI发生的重要新型标志物,具有重要的临床应用价值。
[Abstract]:Objective to investigate the value of urinary liver-type fatty acid binding protein L-FABPin in early diagnosis of the severity of craniocerebral injury and the occurrence of AKI in patients with acute renal injury, and to provide the basis for clinical treatment. Methods 65 patients with craniocerebral trauma with different severity were collected. According to the GCS score, the blood and urine samples were collected at 24 hours and 48 hours after injury, and the serum creatinine levels were measured by biochemical analyzer. Elisa was used to detect urinary L-FABP levels in 15 healthy adults as control. The correlation between serum SCr and urinary L-FABP levels and GCS scores on admission was analyzed. Results the levels of SCr and urinary L-FABP in group B were significantly higher than those in control group. With the decrease of GCS score, the levels of SCr and urinary L-FABP increased gradually. There was a negative correlation between urinary L-FABP and SCr. The incidence of urinary L-FABP was about 21.54. The peak value of urinary L-FABP was 2448 hours after injury, and the increase of urinary L-FABP was significantly earlier than that of SCr. Conclusion urinary L-FABP is significantly earlier than that of SCr. It can be used as an important new type of marker to predict the severity of craniocerebral trauma and to predict the occurrence of AKI. It has important clinical application value.
【作者单位】：中南大学湘雅三医院神经外科;
【基金】：湖南省科技厅科技计划一般项目(2013SK3051)
【分类号】：R651.15

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