急性缺血性卒中患者入院血脂水平及其与出院后不良结局关系

发布时间：2018-04-01 08:06

本文选题：缺血性卒中　切入点：血脂　出处：《中国公共卫生》2017年10期

【摘要】：目的探讨急性缺血性卒中患者入院血脂水平及其出院后不良结局的关系,为急性缺血性卒中的治疗及二级预防提供科学依据。方法采用回顾性队列研究方法于2015年1月1日—2015年8月31日在中国医科大学附属第一医院鞍山医院、丹东市第一医院、辽阳县医院和大洼县医院收集1 614例入院治疗、出院第一诊断为急性缺血性卒中的患者,分析其血脂水平及其与出院后不良结局的关系。结果 1 614例急性缺血性卒中患者的高总胆固醇(TC)、高甘油三酯(TG)和高低密度脂蛋白胆固醇(LDL-C)率分别为37.7%、36.9%和31.0%,低高密度脂蛋白胆固醇(HDL-C)率为19.0%;急性缺血性卒中患者改良Rankin量表(mRS)得分为(1.46±1.79)分,出院不良结局比例为23.3%;在控制了性别、年龄、吸烟、饮酒、高血压病史、糖尿病病史等混杂因素后,多因素非条件logistic回归分析结果显示,TG为1.00~1.39 mmol/L和LDL-C为2.95~3.53 mmol/L对急性缺血性卒中患者出院后短期不良结局具有一定保护作用。结论急性缺血性卒中患者入院时较高TG和LDL-C水平可以减少短期不良结局的发生。
[Abstract]:Objective to investigate the relationship between serum lipid levels and adverse outcomes in patients with acute ischemic stroke after discharge, and to provide scientific basis for the treatment and secondary prevention of acute ischemic stroke.Methods A retrospective cohort study was conducted from January 1, 2015 to August 31, 2015 at Anshan Hospital, the first affiliated Hospital of China Medical University, the first Hospital of Dandong City, Liaoyang County Hospital and Dawa County Hospital.The relationship between blood lipid levels and adverse outcomes after discharge was analyzed in patients with acute ischemic stroke.Results the high total cholesterol (TC), high triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) rates in 1 614 patients with acute ischemic stroke were 37.7% and 31.0%, respectively, and the low density lipoprotein cholesterol (HDL-C) rate was 19.0% in patients with acute ischemic stroke.The score of modified Rankin scale was 1.46 卤1.79.After controlling for gender, age, smoking, drinking, hypertension, diabetes, and other mixed factors,The results of multivariate conditional logistic regression analysis showed that TG was 1.00 卤1.39 mmol/L and LDL-C was 2.95 ~ 3.53 mmol/L, which had a protective effect on the short-term adverse outcome of patients with acute ischemic stroke after discharge from hospital.Conclusion the high levels of TG and LDL-C in patients with acute ischemic stroke at admission can reduce the occurrence of short-term adverse outcomes.
【作者单位】：辽宁省疾病预防控制中心;鞍山市铁西区疾病预防控制中心;丹东市元宝区疾病预防控制中心;辽阳县疾病预防控制中心;大洼区疾病预防控制中心;
【分类号】：R743.3

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